Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.

Abstract : This Letter reports the synthesis and characterization of a new series of water-stable and soluble photosensitizers (PS-CNCs) composed of cellulose nanocrystals (CNCs) bearing polyaminated chlorin p6. With a view to improve cancer cell targeting, these photosensitizers were assayed for their antitumor activity against HaCat cell line. IC(50) values fell within the nanomolar-range, making these photosensitizers promising for further in vitro and in vivo investigations.
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https://hal-unilim.archives-ouvertes.fr/hal-00800917
Contributeur : Vincent Sol <>
Soumis le : jeudi 14 mars 2013 - 16:27:23
Dernière modification le : lundi 3 juin 2019 - 17:08:22

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Nicolas Drogat, Robert Granet, Caroline Le Morvan, Gaëlle Bégaud-Grimaud, Pierre Krausz, et al.. Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2012, 22 (11), pp.3648-52. ⟨10.1016/j.bmcl.2012.04.044⟩. ⟨hal-00800917⟩

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