Photodynamic effects of porphyrin-polyamine conjugates in human breast cancer and keratinocyte cell lines.

Abstract : Porphyrin-polyamine conjugates bearing two (cis or trans position) or four spermidine or spermine units were synthesized. We studied the photostability, the hydrophilic/lipophilic balance of porphyrin-polyamine derivatives and the production of singlet oxygen. All these compounds possess physicochemical features required for their use in PDT. Then, we investigated the photocytotoxic efficacy of these porphyrin-polyamine derivatives and the cell death pathway implicated. All compounds appear to be more efficient than Photofrin® to induce HaCat and MCF7 cell death, essentially by apoptosis. Collectively, these data show that porphyrin-polyamine conjugates could be promising phototherapeutic agents.
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Soumis le : mercredi 18 avril 2012 - 12:14:00
Dernière modification le : mardi 20 mars 2018 - 16:36:32

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Vincent Sarrazy, Guillaume Garcia, Jean-Pierre Mbakidi, Caroline Le Morvan, Gaëlle Bégaud-Grimaud, et al.. Photodynamic effects of porphyrin-polyamine conjugates in human breast cancer and keratinocyte cell lines.. Journal of Photochemistry and Photobiology B: Biology, Elsevier, 2011, 103 (3), pp.201-6. ⟨10.1016/j.jphotobiol.2011.03.005⟩. ⟨hal-00688708⟩

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