Increased levels of circulating microparticles are associated with increased procoagulant activity in patients with cutaneous malignant melanoma.

Abstract : Microparticles (MPs) are known to be increased in various malignancies and are involved in tumor invasion, angiogenesis, coagulation, and metastasis. We investigated the plasma levels of annexin-V MPs (AV(+)MPs), platelet-derived MPs (PMPs), and endothelial-derived MPs (EMPs) in patients with melanoma (n=129) and in healthy controls (n=49). A functional coagulation test STA Procoag-PPL measuring the clotting time was performed on samples containing MPs to evaluate their procoagulant potential. The plasma levels of PMPs, EMPs, and AV(+)MPs were significantly higher, and the clotting time-PPL was significantly lower in melanoma patients than in healthy controls. The plasma levels of PMPs, EMPs, and AV(+)MPs were higher in stage IV than in the other stages of melanoma, but with no significant difference. In addition, we observed an inverse correlation between PMPs, AV(+)MPs, and clotting times. Our data suggest that MPs are involved in the progression of melanoma and may be associated to melanoma-associated thrombogenesis.
Type de document :
Article dans une revue
Journal of Investigative Dermatology, Nature Publishing Group: Open Access Hybrid Model Option A, 2014, 134 (1), pp.176-182. 〈10.1038/jid.2013.288〉
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-01010788
Contributeur : Pascale Viala <>
Soumis le : vendredi 20 juin 2014 - 15:10:30
Dernière modification le : vendredi 20 juin 2014 - 15:10:30

Identifiants

Collections

Citation

Claire Laresche, Fabien Pelletier, Francine Garnache-Ottou, Thomas Lihoreau, Sabeha Biichlé, et al.. Increased levels of circulating microparticles are associated with increased procoagulant activity in patients with cutaneous malignant melanoma.. Journal of Investigative Dermatology, Nature Publishing Group: Open Access Hybrid Model Option A, 2014, 134 (1), pp.176-182. 〈10.1038/jid.2013.288〉. 〈hal-01010788〉

Partager

Métriques

Consultations de la notice

659