Emerging role of IκBζ in inflammation: Emphasis on psoriasis

Preeti Gautam (1) , Sylvain Maenner (1) , Frédéric Cailotto (1) , Pascal Reboul (1) , Stéphane Labialle (1) , Jean‐yves Jouzeau (1) , Frédéric Bourgaud (2) , David Moulin (1)

1 IMoPA - Ingénierie Moléculaire et Physiopathologie Articulaire
2 Plant Advanced Technologies S.A.

Expression of NFKBIZ is stimulated by cytokines such as IL-17, TNFα, IL-1β and IL-36. Increased expression of IκBζ eventually activates NF-κB leading to increased expression of various proinflammatory cytokines, chemokines, as well as psoriasis-associated genes. This cascade of molecules causes recruitment of neutrophils and other immune-mediated inflammatory cells, which consequently leads to the development of psoriasis-like skin inflammation.

Mots clés: psoriasis; ikappabZeta; IκBζ; inflammation; NFKBIZ

Domaines: Sciences du Vivant [q-bio]

Preeti Gautam, Sylvain Maenner, Frédéric Cailotto, Pascal Reboul, Stéphane Labialle, et al.. Emerging role of IκBζ in inflammation: Emphasis on psoriasis. Clinical and Translational Medicine, 2022, 12 (10), pp.e1032. ⟨10.1002/ctm2.1032⟩. ⟨hal-03859806⟩