CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production - Département Métrologie Instrumentation & Information Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2015

CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production

Marielle Saclier
Rémi Mounier
Bénédicte Chazaud

Résumé

Muscle injury triggers inflammation in which infiltrating mononuclear phagocytes are crucial for tissue regeneration. The interaction of the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axis that guides phagocyte infiltration is incompletely understood. Here, we show that CX3CR1 deficiency promotes muscle repair and rescues Ccl2 (-/-) mice from impaired muscle regeneration as a result of altered macrophage function, not infiltration. Transcriptomic analysis of muscle mononuclear phagocytes reveals that Apolipoprotein E (ApoE) is upregulated in mice with efficient regeneration. ApoE treatment enhances phagocytosis by mononuclear phagocytes in vitro, and restores phagocytic activity and muscle regeneration in Ccl2 (-/-) mice. Because CX3CR1 deficiency may compensate for defective CCL2-dependant monocyte recruitment by modulating ApoE-dependent macrophage phagocytic activity, targeting CX3CR1 expressed by macrophages might be a powerful therapeutic approach to improve muscle regeneration.
Fichier principal
Vignette du fichier
ncomms9972.pdf (2.8 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01514445 , version 1 (03-05-2017)

Licence

Paternité

Identifiants

Citer

Ludovic Arnold, Hélène Perrin, Camille Baudesson de Chanville, Marielle Saclier, Patricia Hermand, et al.. CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production. Nature Communications, 2015, 6, pp.8972. ⟨10.1038/ncomms9972⟩. ⟨hal-01514445⟩
877 Consultations
184 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More