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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 1994

The cellular retinoic acid binding protein I is dispensable.

The cellular retinoic acid binding protein I is dispensable.

Résumé

The cellular retinoic acid binding proteins I and II (CRABPI and CRABPII) bind retinoic acid with high affinity, exhibit distinct patterns of expression during embryonic development, and are thought to play important roles in the RA signaling pathway. We have generated a targeted mutation of the CRABPI gene using the "hit-and-run" strategy and shown that it prevents the production of a functional CRABPI protein. Homozygous mutant mice were normal, indicating that CRABPI does not play a crucial role in the RA signaling pathway.
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Dates et versions

hal-02561140 , version 1 (23-11-2020)

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Citer

P. Gorry, T. Lufkin, Andrée Dierich, Cécile Rochette-Egly, D Décimo, et al.. The cellular retinoic acid binding protein I is dispensable.. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 (19), pp.9032-9036. ⟨10.1073/pnas.91.19.9032⟩. ⟨hal-02561140⟩

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