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| HAL: hal-00683520, version 1 |
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| Investigative Ophthalmology & Visual Science 52, 8 (2011) 5105-5110 |
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| Foveal Shape and Structure in a Normal Population |
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| Sarah Tick 1Florence Rossant 2 |
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| (2011-07) |
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| PURPOSE: The shape of the human fovea presents important but still poorly characterized variations. In this study, the variability of the shape and structure of normal foveae were examined. METHODS: In a group of 110 eyes of 57 healthy adults, the shape and structure of the fovea were analyzed by automated segmentation of retinal layer on high-resolution optical coherence tomography scans. In an additional group of 10 normal eyes of 10 patients undergoing fluorescein angiography, the size of the foveal avascular zone (FAZ) was correlated to foveal shape. RESULTS: From the thickest to the thinnest fovea, there was a structural continuum ranging from a shallow pit with continuity of the inner nuclear layer (INL) over the center (seven eyes; 6.7%), to a complete separation of inner layers overlying a flat and thinner central outer nuclear layer (ONL; eight eyes; 7.3%). Central foveal thickness correlated inversely to the degree of inner layer separation and to the surface of the FAZ. CONCLUSIONS: Foveal structure strongly correlates with its neurovascular organization. The findings support a developmental model in which the size of the FAZ determines the extent of centrifugal migration of inner retinal layers, which counteracts in some way the centripetal packing of cone photoreceptors. |
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| 1: | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts |
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Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts |
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| 2: | Laboratoire Traitement et Communication de l'Information [Paris] (LTCI) |
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Télécom ParisTech – CNRS : UMR5141 |
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| 3: | Laboratoire d'Informatique, Signal et Image, Electronique et Télécommunication (LISITE) |
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institut supérieur d'éléctronique de paris |
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| 4: | Sanofi-Aventis R&D |
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SANOFI Recherche |
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| 5: | Département Ophtalmologie |
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Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Lariboisière |
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| 6: | Institut de la vision |
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INSERM : U968 – Université Pierre et Marie Curie (UPMC) - Paris VI – CNRS : UMR7210 |
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| 7: | UFR de Bicêtre |
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Université Paris XI - Paris Sud |
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| 8: | Service de Biophysique et de Médecine Nucléaire |
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AP-HP CHU de Bicêtre |
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| TSI |
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| Subject | : | Life Sciences/Bioengineering/Imaging Computer Science/Medical Imaging |
| hal-00683520, version 1 | |
| http://hal.upmc.fr/hal-00683520 | |
| oai:hal.upmc.fr:hal-00683520 | |
| From: Itebeddine Ghorbel | |
| Submitted on: Thursday, 29 March 2012 09:23:08 | |
| Updated on: Thursday, 29 March 2012 09:23:08 | |
