 |
|
| HAL: hal-00674882, version 1 |
| PubMed: 22155268 |
| DOI: 10.1016/j.fct.2011.11.048 |
| Detailed view |  Export this paper |
 |
| Food and Chemical Toxicology 50, 3-4 (2011) 1134-1148 |
|
|
|
|
| Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: A literature review. |
|
|
| Chelsea Snell 1Aude Bernheim 2 |
|
|
| (2011-12-03) |
|
|
|
| The aim of this systematic review was to collect data concerning the effects of diets containing GM maize, potato, soybean, rice, or triticale on animal health. We examined 12 long-term studies (of more than 90days, up to 2years in duration) and 12 multigenerational studies (from 2 to 5 generations). We referenced the 90-day studies on GM feed for which long-term or multigenerational study data were available. Many parameters have been examined using biochemical analyses, histological examination of specific organs, hematology and the detection of transgenic DNA. The statistical findings and methods have been considered from each study. Results from all the 24 studies do not suggest any health hazards and, in general, there were no statistically significant differences within parameters observed. However, some small differences were observed, though these fell within the normal variation range of the considered parameter and thus had no biological or toxicological significance. If required, a 90-day feeding study performed in rodents, according to the OECD Test Guideline, is generally considered sufficient in order to evaluate the health effects of GM feed. The studies reviewed present evidence to show that GM plants are nutritionally equivalent to their non-GM counterparts and can be safely used in food and feed. |
|
|
|
|
|
|
|
|
|
|
|
| 1: | University of Nottingham, School of Biosciences |
|
|
|
University of Nottingham |
|
|
| 2: | Mathématiques et Informatique Appliquées (MIA) |
|
|
|
Institut national de la recherche agronomique (INRA) : UMR0518 – AgroParisTech |
|
|
| 3: | Anthala |
|
|
|
Anthala |
|
|
| 4: | Laboratoire de physiologie cellulaire végétale (LPCV) |
|
|
|
CNRS : UMR5168 – Institut national de la recherche agronomique (INRA) : UR1200 – CEA : DSV/IRTSV – Université Joseph Fourier - Grenoble I |
|
|
| 5: | institut de Recherches en Technologies et Sciences pour le Vivant (iRTSV) |
|
|
|
INSERM : IFR27 – CNRS : IFR27 – Institut national de la recherche agronomique (INRA) – CEA |
|
|
| 6: | Mét@risk |
|
|
|
Institut national de la recherche agronomique (INRA) : UR1204 |
|
|
| 7: | Xénobiotiques |
|
|
|
Institut national de la recherche agronomique (INRA) : UR1089 – Ecole Nationale Vétérinaire de Toulouse |
|
|
| 8: | Ecologie, Systématique et Evolution (ESE) |
|
|
|
CNRS : UMR8079 – Université Paris XI - Paris Sud – AgroParisTech |
|
|
|
|
|
|
|
|
|
| Subject | : | Life Sciences/Vegetal Biology Life Sciences/Toxicology |
|
|
| genetically modified organism – transgenic plant – Zea mays – Solanum tuberosum – Glycine max – Oryza sativa – Triticum – animal feeding trial – safety assessment – nutritional assessment – long term studies – multigenerational studies |
|
| hal-00674882, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00674882 | |
| oai:hal.archives-ouvertes.fr:hal-00674882 | |
| From: Jacqueline Martin-Laffon | |
| Submitted on: Tuesday, 28 February 2012 13:50:34 | |
| Updated on: Friday, 5 October 2012 11:56:47 | |
