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| HAL: hal-00654811, version 1 |
| PubMed: 21397039 |
| DOI: 10.1016/j.jbi.2011.03.002 |
| CEMOA: http://cemadoc.irstea.fr/cemoa/PUB00031493 |
| Detailed view |  Export this paper |
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| Journal of Biomedical Informatics 44 Suppl 1, suppl 1 (2011) S12-6 |
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| Mining microarray data to predict the histological grade of a breast cancer |
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Michael Fabregue 1Sandra Bringay 1 |
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| (2011-12) |
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| BACKGROUND: The aim of this study was to develop an original method to extract sets of relevant molecular biomarkers (gene sequences) that can be used for class prediction and can be included as prognostic and predictive tools. MATERIALS AND METHODS: The method is based on sequential patterns used as features for class prediction. We applied it to classify breast cancer tumors according to their histological grade. RESULTS: We obtained very good recall and precision for grades 1 and 3 tumors, but, like other authors, our results were less satisfactory for grade 2 tumors. CONCLUSIONS: We demonstrated the interest of sequential patterns for class prediction of microarrays and we now have the material to use them for prognostic and predictive applications. |
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| 1: | Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM) |
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CNRS : UMR5506 – Université Montpellier II - Sciences et techniques |
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| 2: | Territoires, Environnement, Télédétection et Information Spatiale (UMR TETIS) |
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Irstea – Centre de coopération internationale en recherche agronomique pour le développement [CIRAD] : UMR91 – AgroParisTech |
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| 3: | Institut de recherche en cancérologie de Montpellier (IRCM) |
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INSERM : U896 – Université Montpellier I – CRLCC Val d'Aurelle - Paul Lamarque |
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| Subject | : | Environmental Sciences Life Sciences/Cancer |
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| METHODOLOGIE – BIOMARQUEUR – MANIFESTATION DE MALADIE – SEQUENTIAL PATTERNS – MICROARRAYS ANALYSIS – BREAST CANCER – TRANSLATIONAL BIOINFORMATICS – CANCER |
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| hal-00654811, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00654811 | |
| oai:hal.archives-ouvertes.fr:hal-00654811 | |
| From: Import Ws Irstea | |
| Submitted for: | |
| Submitted on: Friday, 23 December 2011 09:52:33 | |
| Updated on: Thursday, 16 May 2013 19:51:20 | |
