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| HAL: hal-00630150, version 2 |
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| 9th annual conference on Theory and Applications of Models of Computation (TAMC), Beijing : China (2012) |
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| Available versions: | v1 (2011-10-07) | v2 (2012-03-16) |
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| An Algorithmic View on Multi-related-segments: a new unifying model for approximate common interval |
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| Xiao Yang 1Florian Sikora 2, 3 |
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| (2012-03) |
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| A set of genes that are proximately located on multiple chromosomes often implies their origin from the same ancestral genomic segment or their involvement in the same biological process. Among the numerous studies devoted to model and infer these gene sets, the recently introduced approximate common interval (ACI) models capture gene loss events in addition to the gene insertion, duplication and inversion events already incorporated by earlier models. However, the computational tractability of the corresponding problems remains open in most of the cases. In this contribution, we propose a unifying model for ACI, namely Multi-related-segments (Mrs), and demonstrate that capturing gene losses induces intractability in many cases (answering an open question raised in [19,20]). |
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| 1: | DECE |
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Iowa State University |
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| 2: | Laboratoire d'Informatique Gaspard-Monge (LIGM) |
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Université Paris-Est Marne-la-Vallée (UPEMLV) – ESIEE – Ecole des Ponts ParisTech – Fédération de Recherche Bézout – CNRS : UMR8049 |
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| 3: | Lehrstuhl Bioinformatik Jena |
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Friedrich-Schiller Universität Jena |
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| 4: | Département d'Informatique et de Recherche Opérationnelle [Montreal] (DIRO) |
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Université de Montréal |
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| 5: | Dipartimento di Matematica e Informatica - Universita Udine (DIMI) |
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Università degli studi di Udine |
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| Algorithmics |
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| Subject | : | Computer Science/Bioinformatics Life Sciences/Quantitative Methods |
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| Attached file list to this document: | |||||
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| hal-00630150, version 2 | |
| http://hal-upec-upem.archives-ouvertes.fr/hal-00630150 | |
| oai:hal-upec-upem.archives-ouvertes.fr:hal-00630150 | |
| From: Guillaume Blin | |
| Submitted on: Thursday, 15 March 2012 13:47:54 | |
| Updated on: Friday, 16 March 2012 16:41:14 | |
