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Laboratoire d'écologie fonctionnelle |  |
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Laboratoire d'écologie fonctionnelle | |
| HAL: hal-00618366, version 1 |
| PubMed: 1669292 |
| DOI: 10.1002/hipo.450010206 |
| Detailed view |  Export this paper |
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| Hippocampus 1, 2 (1991) 181-92 |
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| Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation. |
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| T. Otto 1H. Eichenbaum |
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| (1991-04) |
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| Recent studies have revealed 3 stimulation parameters that together comprise the temporal pattern of neuronal activation optimal for the induction of hippocampal LTP: high-frequency bursts, activity 100-200 ms prior to a burst, and burst delivery in phase with the ongoing hippocampal theta rhythm. The present paper reports that these 3 aspects of patterned neural activity, collectively referred to as "theta-bursting," are characteristic of the spike trains of CA1 pyramidal cells in rats during the sampling and analysis of learning cues in an odor discrimination task and during performances of a spatial memory task. In contrast, theta-bursting occurs relatively infrequently during behavioral events less directly related to task-relevant mnemonic processing. These findings suggest that the optimal conditions for the induction of LTP occur naturally in behaving animals, time-locked to behavioral events critical to learning. |
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| 1: | Laboratoire Ecologie Fonctionnelle et Environnement (EcoLab) |
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PRES Université de Toulouse – Institut National Polytechnique de Toulouse - INPT – Université Paul Sabatier [UPS] - Toulouse III – Observatoire Midi-Pyrénées – CNRS : UMR5245 |
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| 2: | Laboratoire de Physiologie de la Perception et de l'Action (LPPA) |
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CNRS : UMR7152 – Collège de France |
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| Subject | : | Cognitive science/Neuroscience |
| hal-00618366, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00618366 | |
| oai:hal.archives-ouvertes.fr:hal-00618366 | |
| From: Sidney I Wiener | |
| Submitted on: Thursday, 1 September 2011 15:10:01 | |
| Updated on: Thursday, 1 September 2011 15:10:01 | |
