 |
Observatoire Midi-Pyrénées |  |
|
Observatoire Midi-Pyrénées | |
| HAL: hal-00437674, version 1 |
| PubMed: 19525076 |
| DOI: 10.1016/j.ejrad.2009.05.025 |
| Detailed view |  Export this paper |
 |
| European Journal of Radiology 72, 1 (2009) 22-6 |
|
|
|
|
| Liposarcoma or lipoma: does genetics change classic imaging criteria? |
|
|
F. Bidault 1D. Vanel 2 |
|
|
| (2009-10) |
|
|
|
| Differentiating benign from malignant fatty tumours has always been very difficult for both radiologists and pathologists. Cytogenetic and molecular genetic analyses provide complementary tools for differentiating soft tissue tumours. Our objective was to compare imaging criteria of malignancy with a new diagnostic gold standard, namely, pathological analysis combined with cytogenetic and molecular genetic analyses. Nineteen patients with a fatty tumour were included. All had computed tomography and/or magnetic resonance imaging examination before any biopsy or surgery. All had histopathological and cytogenetic and/or molecular genetic analyses. The imaging diagnosis of benign or malignant lesions was accurate in 15 cases, with 4 false positives for malignancy. Erroneous criteria were a large size (4 cases), and a mass that was not purely fatty. In conclusion, the main pitfall for a false positive radiological diagnosis of liposarcoma is certainly a large-sized tumour. Cytogenetic and molecular genetic analyses contribute to the diagnosis and can be performed at the same time with a core biopsy. |
|
|
|
|
|
|
|
|
|
|
|
| 1: | Département de radiothérapie |
|
|
|
Institut Gustave Roussy |
|
|
| 2: | Institut Gustave Roussy (IGR) |
|
|
|
Institut Gustave Roussy |
|
|
| 3: | Département de Biologie et pathologie médicale |
|
|
|
Institut Gustave Roussy |
|
|
| 4: | Laboratoire des Mécanismes et Transfert en Géologie (LMTG) |
|
|
|
CNRS : UMR5563 – Observatoire Midi-Pyrénées – Université Paul Sabatier [UPS] - Toulouse III – Institut de recherche pour le développement [IRD] : UMR154 |
|
|
| 5: | Institut de signalisation, biologie du développement et cancer (ISBDC) |
|
|
|
CNRS : UMR6543 – Université Nice Sophia Antipolis [UNS] |
|
|
| 6: | Service de Génétique Oncologique |
|
|
|
Institut Curie – Université Paris V - Paris Descartes |
|
|
|
|
|
|
|
|
|
| Subject | : | Life Sciences/Development Biology |
| hal-00437674, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00437674 | |
| oai:hal.archives-ouvertes.fr:hal-00437674 | |
| From: Yvette Benhamou | |
| Submitted on: Tuesday, 1 December 2009 11:20:57 | |
| Updated on: Tuesday, 1 December 2009 11:20:57 | |
