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Observatoire Midi-Pyrénées |  |
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Observatoire Midi-Pyrénées | |
| HAL: hal-00174364, version 1 |
| PubMed: 16871334 |
| PubMed Central: 1488899 |
| DOI: 10.1371/journal.pctr.0010012 |
| Detailed view |  Export this paper |
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| The New England Journal of Medicine 1, 2 (2006) e12 |
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| Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. |
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| Thorkild I. A. Sørensen 1Philippe Boutin 1 |
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| (2006-06) |
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| OBJECTIVES: To study if genes with common single nucleotide polymorphisms (SNPs) associated with obesity-related phenotypes influence weight loss (WL) in obese individuals treated by a hypo-energetic low-fat or high-fat diet. DESIGN: Randomised, parallel, two-arm, open-label multi-centre trial. SETTING: Eight clinical centres in seven European countries. PARTICIPANTS: 771 obese adult individuals. INTERVENTIONS: 10-wk dietary intervention to hypo-energetic (-600 kcal/d) diets with a targeted fat energy of 20%-25% or 40%-45%, completed in 648 participants. OUTCOME MEASURES: WL during the 10 wk in relation to genotypes of 42 SNPs in 26 candidate genes, probably associated with hypothalamic regulation of appetite, efficiency of energy expenditure, regulation of adipocyte differentiation and function, lipid and glucose metabolism, or production of adipocytokines, determined in 642 participants. RESULTS: Compared with the noncarriers of each of the SNPs, and after adjusting for gender, age, baseline weight and centre, heterozygotes showed WL differences that ranged from -0.6 to 0.8 kg, and homozygotes, from -0.7 to 3.1 kg. Genotype-dependent additional WL on low-fat diet ranged from 1.9 to -1.6 kg in heterozygotes, and from 3.8 kg to -2.1 kg in homozygotes relative to the noncarriers. Considering the multiple testing conducted, none of the associations was statistically significant. CONCLUSIONS: Polymorphisms in a panel of obesity-related candidate genes play a minor role, if any, in modulating weight changes induced by a moderate hypo-energetic low-fat or high-fat diet. |
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| 1: | Génétique des maladies multifactorielles (GMM) |
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CNRS : UMR8090 – Université Lille II - Droit et santé |
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| 2: | Centre de recherche cerveau et cognition (CERCO) |
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CNRS : UMR5549 – Université Paul Sabatier [UPS] - Toulouse III |
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| 3: | Laboratoire de mécanique de Lille (LML) |
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CNRS : UMR8107 – Université Lille I - Sciences et technologies – Ecole Centrale de Lille – Arts et Métiers ParisTech |
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| 4: | Déterminants Biologiques et Comportementaux des Obésités |
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Assistance publique - Hôpitaux de Paris (AP-HP) – Hôtel-Dieu – Université Pierre et Marie Curie [UPMC] - Paris VI – EA3502 |
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| 5: | Service de nutrition |
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Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital de l'Hôtel-Dieu |
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| 6: | Nutrition et obésité : approches génétique et transcriptomique |
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INSERM : U755 – IFR58 – Université Pierre et Marie Curie [UPMC] - Paris VI |
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| 7: | Département de nutrition |
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Assistance publique - Hôpitaux de Paris (AP-HP) – Hôtel-Dieu |
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| 8: | Laboratoire des Amino-acides Peptides et Protéines (LAPP) |
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CNRS : UMR5810 – Université Montpellier I – Université Montpellier II - Sciences et techniques |
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| 9: | Techniques of Informatics and Microelectronics for integrated systems Architecture (TIMA) |
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CNRS : UMR5159 – Université Joseph Fourier - Grenoble I – Institut National Polytechnique de Grenoble (INPG) |
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| 10: | Centre d'études spatiales de la biosphère (CESBIO) |
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CNRS : UMR5126 – Institut de recherche pour le développement [IRD] – CNES – Observatoire Midi-Pyrénées – INSU – Université Paul Sabatier [UPS] - Toulouse III |
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| 11: | Gestion environnementale et traitement biologique des déchets (UR GERE) |
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CEMAGREF |
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| 12: | Systèmes Macromoléculaires et Physiopathologie Humaine (SMPH) |
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BIOMERIEUX – CNRS : UMR2714 |
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| 13: | Institut des Biomolécules Max Mousseron (IBMM) |
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CNRS : UMR5247 – Université Montpellier I – Université Montpellier II - Sciences et techniques |
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| 14: | Unité de recherche sur les obésités |
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INSERM : U586 – IFR31 – Université Paul Sabatier [UPS] - Toulouse III |
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| 15: | Département de nutrition |
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Hôtel-Dieu – Université Pierre et Marie Curie [UPMC] - Paris VI |
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| 16: | Department of Sport Medicine |
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Charles University |
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| 17: | Section of Genomic Medicine |
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Imperial College |
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| 18: | Genome Centre |
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Imperial College London – Hammersmith campus |
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| Subject | : | Life Sciences/Genetics/Human genetics |
| hal-00174364, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00174364 | |
| oai:hal.archives-ouvertes.fr:hal-00174364 | |
| From: Philippe Froguel | |
| Submitted on: Monday, 24 September 2007 10:33:59 | |
| Updated on: Friday, 23 April 2010 10:29:04 | |
