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Nucleic Acids Research (2012) 303-309
CSA: Comprehensive comparison of pairwise protein structure alignments
Inken Wohlers ( ) 1, Noël Malod-Dognin 2, Rumen Andonov 3, Gunnar W. Klau 1
For the Life Sciences, Centrum Wiskunde & Informatica, Science Park 123, 1098 XG Amsterdam, the Netherlands collaboration(s)
(2012)

CSA is a web server for the comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl
1:  Life Sciences (MAC4)
Centrum Wiskunde & Informatica
2:  ABS (INRIA Sophia Antipolis)
INRIA
3:  GENSCALE (INRIA - IRISA)
INRIA – CNRS : UMR6074 – Université de Rennes 1 – École normale supérieure de Cachan - ENS Cachan
Computer Science/Bioinformatics

Life Sciences/Quantitative Methods
Protein structure alignments – alignment comparison – web server – exact algorithm – scoring function
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