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| HAL: inria-00331281, version 1 |
| See detailed view |  BibTeX,EndNote,... |
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| Theoretical Biology Insights 1 (2008) 13-22 |
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| From Molecules to Organisms: Towards Multiscale Integrated Models of Biological Systems |
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| Christophe Lavelle 1, 2, 3Hugues Berry 4 |
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| (2008) |
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| A consensus has recently emerged that further progress in understanding human physiopathology will demand integrative views of biological systems. In this context, complex systems and related interdisciplinary approaches of biology are expected to help. The aim of this collective paper is basically to provide a starting point for further discussions and interactions within the community of complex systems biologists. After briefly introducing some general concepts, we present four major challenges that should be tackled in the next years. These represent future directions that we isolated as priority concerns for modern biology. Suggestions of how to reach these destinations are provided, with the hope that they will soon lead to concrete advances towards fully consistent multiscale models of biological systems and a better understanding of physiopathology. |
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| 1: | Institut Jacques Monod (IJM) |
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CNRS : UMR7592 – Université Paris VII - Paris Diderot |
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| 2: | Laboratoire de Physique Théorique de la Matière Condensée (LPTMC) |
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CNRS : UMR7600 – Université Pierre et Marie Curie [UPMC] - Paris VI |
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| 3: | Institut Gustave Roussy (IGR) |
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Institut Gustave Roussy |
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| 4: | ALCHEMY (INRIA Futurs) |
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INRIA – CNRS : UMR8623 – Université Paris XI - Paris Sud |
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| 5: | NMDA : Neurogenèse et morphogenèse dans le développement et chez l'adulte (NNMDDCA) |
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CNRS : UMR6156 – Université de la Méditerranée - Aix-Marseille II |
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| 6: | Institut de Biologie du Développement de Marseille Luminy (IBDML) |
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CNRS : UMR6216 – Université de la Méditerranée - Aix-Marseille II |
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| 7: | Développement, évolution et plasticité du système nerveux (DEPSN) |
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CNRS : UPR2197 |
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| 8: | Institut de Neurobiologie Alfred Fessard (INAF) |
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CNRS : FRC2118 |
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| 9: | Institut de Recherche Mathématique de Rennes (IRMAR) |
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CNRS : UMR6625 – Université de Rennes 1 – École normale supérieure de Cachan - ENS Cachan – Institut National des Sciences Appliquées (INSA) : - RENNES – Université de Rennes II - Haute Bretagne |
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| 10: | SYMBIOSE (INRIA - IRISA) |
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CNRS : UMR6074 – INRIA – Institut National des Sciences Appliquées (INSA) - Rennes – Université de Rennes 1 |
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| 11: | Biologie et thérapeutique des pathologies immunitaires (BTPI) |
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CNRS : UMR7087 – Université Pierre et Marie Curie [UPMC] - Paris VI |
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| 12: | Centre de recherche en épistémologie appliquée (CREA) |
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CNRS : UMR7656 – Polytechnique - X |
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| inria-00331281, version 1 | |
| http://hal.inria.fr/inria-00331281 | |
| oai:hal.inria.fr:inria-00331281 | |
| From: Ovidiu Radulescu | |
| Submitted on: Thursday, 16 October 2008 10:31:13 | |
| Updated on: Wednesday, 24 March 2010 09:30:03 | |
