 |
 |
 |
|
|
|
| HAL: hal-00625096, version 1 |
| PubMed: 20844136 |
| DOI: 10.1523/JNEUROSCI.3135-10.2010 |
| Detailed view |  Export this paper |
 |
| Journal of Neuroscience 30, 37 (2010) 12414-23 |
|
|
|
|
| Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. |
|
|
| Eduardo GasconStéphane Gaillard 1 |
|
|
| (2010-09-15) |
|
|
|
| Nociceptors in peripheral ganglia display a remarkable functional heterogeneity. They can be divided into the following two major classes: peptidergic and nonpeptidergic neurons. Although RUNX1 has been shown to play a pivotal role in the specification of nonpeptidergic neurons, the mechanisms driving peptidergic differentiation remain elusive. Here, we show that hepatocyte growth factor (HGF)-Met signaling acts synergistically with nerve growth factor-tyrosine kinase receptor A to promote peptidergic identity in a subset of prospective nociceptors. We provide in vivo evidence that a population of peptidergic neurons, derived from the RUNX1 lineage, require Met activity for the proper extinction of Runx1 and optimal activation of CGRP (calcitonin gene-related peptide). Moreover, we show that RUNX1 in turn represses Met expression in nonpeptidergic neurons, revealing a bidirectional cross talk between Met and RUNX1. Together, our novel findings support a model in which peptidergic versus nonpeptidergic specification depends on a balance between HGF-Met signaling and Runx1 extinction/maintenance. |
|
|
|
|
|
|
|
|
|
|
|
| 1: | Institut de Mathématiques de Bordeaux (IMB) |
|
|
|
CNRS : UMR5251 – Université Sciences et Technologies - Bordeaux I – Université Victor Segalen - Bordeaux II |
|
|
| 2: | Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M) |
|
|
|
CNRS : UMR6231 – Université de la Méditerranée - Aix-Marseille II – Université Paul Cézanne - Aix-Marseille III |
|
|
| 3: | Institut de Biologie du Développement de Marseille Luminy (IBDML) |
|
|
|
CNRS : UMR6216 – Université de la Méditerranée - Aix-Marseille II |
|
|
|
|
|
|
|
|
|
| Subject | : | Life Sciences/Biochemistry, Molecular Biology/Biomolecules |
| hal-00625096, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00625096 | |
| oai:hal.archives-ouvertes.fr:hal-00625096 | |
| From: Corinne Dumonceaud | |
| Submitted on: Tuesday, 20 September 2011 17:01:56 | |
| Updated on: Friday, 18 November 2011 16:55:45 | |
