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| HAL : hal-00287094, version 1 |
| PubMed : 15644210 |
| DOI : 10.1016/j.jmb.2004.11.015 |
| Fiche détaillée |  Récupérer au format |
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| Journal of Molecular Biology 345, 5 (2005) 1131-9 |
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| The crystal structure of annexin A8 is similar to that of annexin A3. |
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| Stéphane Réty 1, 2Jana Sopková-De Oliveira Santos 2, 3 |
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| (04/02/2005) |
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| Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship. |
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| 1 : | Laboratoire de Biotechnologie et Pharmacologie génétique Appliquée (LBPA) |
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CNRS : UMR8113 – École normale supérieure de Cachan - ENS Cachan |
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| 2 : | Laboratoire pour l'utilisation du rayonnement électromagnétique (LURE) |
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CNRS : UMR130 – CEA – MENRT |
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| 3 : | CERMN |
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Université de Caen Basse-Normandie |
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| 4 : | Signalisation, inflammation et transformation cellulaire |
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INSERM : U332 |
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| 5 : | Institut de Génetique Moléculaire (IGM) |
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Université Paris XI - Paris Sud |
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| 6 : | Institute of Microbiology |
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Académie de Sciences Tchèque |
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| 7 : | Interactions cellulaires et moléculaires (ICM) |
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CNRS : UMR6026 – Université de Rennes 1 – IFR140 |
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| 8 : | Centre de Ressources Informatiques (CRI) |
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Université Paris XI - Paris Sud |
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| 9 : | BIONEXIS |
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Aucune |
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| Domaine | : | Sciences du Vivant/Biochimie, Biologie Moléculaire/Biologie structurale |
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| Annexin A8 – Crystal structure – Calcium binding |
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| hal-00287094, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00287094 | |
| oai:hal.archives-ouvertes.fr:hal-00287094 | |
| Contributeur : Anita Lewit-Bentley | |
| Soumis le : Mercredi 11 Juin 2008, 14:07:55 | |
| Dernière modification le : Mercredi 11 Juin 2008, 14:07:55 | |
