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| HAL : hal-00720515, version 1 |
| arXiv : 1207.5725 |
| Voir la fiche détaillée |  BibTeX,EndNote,... |
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| Anomalous versus non-homogeneous diffusion in the ligand-binding equilibrium: when size matters |
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Hédi Soula 1, 2Bertrand Caré 1, 2, 3 |
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| (24/07/2012) |
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| Measurements of protein motion in living cells and membranes consistently report transient anomalous subdiffusion which converges back to a Brownian motion with reduced diffusion constant at long times, after the subdiffusion regime. On the other hand, membranes are also non-homogeneous media in which Brownian motion may be locally slowed-down due to variations in lipid composition. Here, we investigate whether both situations lead to a similar behavior for the reversible ligand-binding reaction in 2d. We compare the (long-time) equilibrium properties obtained with transient anomalous diffusion to those obtained with slowed-down Brownian motion. We show that both processes increase the apparent affinity of the reaction. However, in the case of slowed-down Brownian motion, the affinity is maximal when the slowdown is restricted to a subregion of the available space. Hence, these two processes are different: size matters for slowed-down Brownian motion, not for transient anomalous subdiffusion. |
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| 1 : | BEAGLE (Insa Lyon / INRIA Grenoble Rhône-Alpes / UCBL) |
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INRIA – Institut National des Sciences Appliquées (INSA) - Lyon – Université Claude Bernard - Lyon I |
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| 2 : | Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition (CARMEN) |
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INSERM : U1060 – Institut national de la recherche agronomique (INRA) – Institut National des Sciences Appliquées (INSA) - Lyon – Université Claude Bernard - Lyon I – Hospices Civils de Lyon |
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| 3 : | Laboratoire d'InfoRmatique en Images et Systèmes d'Information (LIRIS) |
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CNRS : UMR5205 – Université Claude Bernard - Lyon I – Université Lumière - Lyon II – Institut National des Sciences Appliquées (INSA) - Lyon – Ecole Centrale de Lyon |
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| Domaine | : | Sciences du Vivant/Bio-Informatique, Biologie Systémique Physique/Physique/Biophysique Informatique/Bio-informatique |
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| Liste des fichiers attachés à ce document : | |||||
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| hal-00720515, version 1 | |
| http://hal.inria.fr/hal-00720515 | |
| oai:hal.inria.fr:hal-00720515 | |
| Contributeur : Hugues Berry | |
| Soumis le : Mardi 24 Juillet 2012, 16:53:46 | |
| Dernière modification le : Mardi 24 Juillet 2012, 17:21:08 | |
