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Numerical studies on the effect of electric pulses on an egg-shaped cell with a spherical nucleus
François Buret 1, Nicolas Faure 1, Laurent Nicolas 1, Ronan Perrussel ( ) 1, Clair Poignard ( ) 2, 3
Laboratoire Ampère, Ecole Centrale de Lyon Collaboration(s)
(29/04/2010)

In this paper, we study the influence of nanosecond electrical pulses on the phenomena arising in a biological cell model composed of a nucleus embedded in a cytoplasm, both entities being surrounded by a thin resistive membrane. The time-harmonic and the time-transient equations of the electric potential are presented, and accurate approximations of these equations are given, that avoid to mesh the thin resistive membranes. Numerical formulations of the partial differential equations are derived and simulations are performed in order to study the sensitivity of an eukaryotic cell to the orientation, the amplitude and the duration of the applied electric pulses.
1 :  Ampère
CNRS : UMR5005 – Université Claude Bernard - Lyon I – Institut National des Sciences Appliquées (INSA) - Lyon – Ecole Centrale de Lyon
2 :  Institut de Mathématiques de Bordeaux (IMB)
CNRS : UMR5251 – Université Sciences et Technologies - Bordeaux I – Université Victor Segalen - Bordeaux II
3 :  MC2 (INRIA Bordeaux - Sud-Ouest)
INRIA – Université Sciences et Technologies - Bordeaux I – Université Victor Segalen - Bordeaux II – CNRS : UMR
Mathématiques/Equations aux dérivées partielles
Electroporation modelling – Finite element methods – Variational formulation – Electric potential
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