%0 Journal Article
%T Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity
%+ Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
%+ Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
%+ Département de neurologie [Montpellier]
%+ Département de Neuroradiologie[Montpellier]
%+ Institut d’Imagerie Fonctionnelle Humaine [CHU Montpellier] (I2FH)
%+ Laboratoire Charles Coulomb (L2C)
%+ Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp)
%+ Université de Lausanne = University of Lausanne (UNIL)
%+ Ecole Polytechnique Fédérale de Lausanne (EPFL)
%A Ayrignac, Xavier
%A Le Bars, Emmanuelle
%A Duflos, Claire
%A Hirtz, Christophe
%A Maleska Maceski, Aleksandra
%A Carra-Dallière, Clarisse
%A Charif, Mahmoud
%A Pinna, Frédéric
%A Prin, Pauline
%A Menjot de Champfleur, Nicolas
%A Deverdun, Jérémy
%A Kober, Tobias
%A Marechal, Bénédicte
%A Fartaria, Mario Joao
%A Corredor Jerez, Ricardo
%A Labauge, Pierre
%A Lehmann, Sylvain
%< avec comité de lecture
%@ 2045-2322
%J Scientific Reports
%I Nature Publishing Group
%V 10
%N 1
%P 10923
%8 2020-07-02
%D 2020
%R 10.1038/s41598-020-67934-2
%M 32616916
%Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
%Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
%Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles
%X Neurofilament light chain (NfL) has been demonstrated to correlate with multiple sclerosis disease severity as well as treatment response. Nevertheless, additional serum biomarkers are still needed to better differentiate disease activity from disease progression. The aim of our study was to assess serum glial fibrillary acid protein (s-GFAP) and neurofilament light chain (s-NfL) in a cohort of 129 multiple sclerosis (MS) patients. Eighteen primary progressive multiple sclerosis (PPMS) and 111 relapsing remitting MS (RRMS) were included. We showed that these 2 biomarkers were significantly correlated with each other (R = 0.72, p < 0.001). Moreover, both biomarkers were higher in PPMS than in RRMS even if multivariate analysis only confirmed this difference for s-GFAP (130.3 ± 72.8 pg/ml vs 83.4 ± 41.1 pg/ml, p = 0.008). Finally, s-GFAP was correlated with white matter lesion load and inversely correlated with WM and GM volume. Our results seem to confirm the added value of s-GFAP in the context of multiple sclerosis.
%G English
%2 https://inserm.hal.science/inserm-02904593/document
%2 https://inserm.hal.science/inserm-02904593/file/s41598-020-67934-2.pdf
%L inserm-02904593
%U https://inserm.hal.science/inserm-02904593
%~ INSERM
%~ CNRS
%~ UNIV-MONTP1
%~ SANTE_PUB_INSERM
%~ L2C
%~ MIPS
%~ BS
%~ UNIV-MONTPELLIER
%~ PHYMEDEXP
%~ UM-2015-2021