Genolevures: protein families and synteny among complete hemiascomycetous yeast proteomes and genomes.

David James Sherman (1, 2, 3) , Tiphaine Martin (1, 4) , Macha Nikolski (1, 3) , Cyril Cayla (3) , Jean-Luc Souciet (5, 6) , Pascal Durrens (1, 3)

1 MAGNOME - Models and Algorithms for the Genome
2 CBIB - Centre de Bioinformatique de Bordeaux
3 LaBRI - Laboratoire Bordelais de Recherche en Informatique
4 MABIOVIS - Modèles et algorithmes pour la Bioinformatique et la Visualisation d'informations;
5 DEEGM - Dynamique, évolution et expression de génomes de microorganismes
6 GMGM - Génétique moléculaire, génomique, microbiologie

The Genolevures online database (http://cbi.labri.fr/Genolevures/ and http://genolevures.org/) provides exploratory tools and curated data sets relative to nine complete and seven partial genome sequences determined and manually annotated by the Genolevures Consortium, to facilitate comparative genomic studies of Hemiascomycete yeasts. The 2008 update to the Genolevures database provides four new genomes in complete (subtelomere to subtelomere) chromosome sequences, 50 000 protein-coding and tRNA genes, and in silico analyses for each gene element. A key element is a novel classification of conserved multi-species protein families and their use in detecting synteny, gene fusions and other aspects of genome remodeling in evolution. Our purpose is to release high-quality curated data from complete genomes, with a focus on the relations between genes, genomes and proteins.

Domaines: Bio-informatique [q-bio.QM]; Bio-Informatique, Biologie Systémique [q-bio.QM]

David James Sherman, Tiphaine Martin, Macha Nikolski, Cyril Cayla, Jean-Luc Souciet, et al.. Genolevures: protein families and synteny among complete hemiascomycetous yeast proteomes and genomes.. Nucleic Acids Research, 2009, 37, pp.D550-D554. ⟨10.1093/nar/gkn859⟩. ⟨inria-00341578⟩