 |
|
|
|
| HAL: inria-00089218, version 2 |
| See detailed view |  BibTeX,EndNote,... |
|
|
| Transactions on Computational Systems Biology Lecture Notes in Bioinformatics 4230, (VII) (2006) 24-55 |
|
|
| Available versions | v1 (2006-08-13) | v2 (2006-08-18) |
|
|
|
|
| Gene Regulation in the Pi Calculus: Simulating Cooperativity at the Lambda Switch |
|
|
Céline Kuttler 1Joachim Niehren 2, 3 |
|
|
| (2006) |
|
|
|
| We propose to model the dynamics of gene regulatory networks as concurrent processes in the stochastic pi calculus. As a first case study, we show how to express the control of transcription initiation at the lambda switch, a prototypical example where cooperative enhancement is crucial. This requires concurrent programming techniques that are new to systems biology, and necessitates stochastic parameters that we derive from the literature. We test all components of our model by exhaustive stochastic simulations. A comparison with previous results reported in the literature, experimental and simulation based, confirms the appropriateness of our modeling approach. |
|
|
|
|
|
|
|
|
|
|
|
| 1: | Institut de recherche interdisciplinaire (IRI) |
|
|
|
CNRS : FR2831 – Université des Sciences et Technologies de Lille - Lille I – Université du Droit et de la Santé - Lille II |
|
|
| 2: | MOSTRARE (INRIA Futurs) |
|
|
|
INRIA – CNRS : UMR8022 – Université des Sciences et Technologies de Lille - Lille I : EA3588 – Université Charles de Gaulle - Lille III |
|
|
| 3: | BIOCOMPUTING (LIFL) |
|
|
|
Université des Sciences et Technologies de Lille - Lille I – CNRS : UMR8022 |
|
|
|
|
|
|
|
|
|
| Domain | : | Computer Science/Programming Languages Computer Science/Bioinformatics Life Sciences/Quantitative Methods |
|
|
| Attached file list to this document: | |||||
|
|||||
|
|
|
| inria-00089218, version 2 | |
| http://hal.inria.fr/inria-00089218 | |
| oai:hal.inria.fr:inria-00089218 | |
| From: Joachim Niehren | |
| Submitted on: Sunday, 13 August 2006 21:58:37 | |
| Updated on: Tuesday, 1 June 2010 15:37:33 | |
