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This review summarizes the state of the art in the synthesis of well-defined glycopolymers by Reversible-Deactivation Radical Polymerization (RDRP) from its inception in 1998 until August 2012. Glycopolymers architectures have been successfully synthesized with four major RDRP techniques: Nitroxide-mediated radical polymerization (NMP), cyanoxyl-mediated radical polymerization (CMRP), atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization. Over 140 publications were analyzed and their results summarized according to the technique used and the type of monomer(s) and carbohydrates involved. Particular emphasis was placed on the experimental conditions used, the structure obtained (comonomer distribution, topology), the degree of control achieved and the (potential) applications sought. A list of representative examples for each polymerization process can be found in tables placed at the beginning of each section covering a particular RDRP technique.
1,6-Bis(1-imidazolyl)-2,4-hexadiyne (1) and1,6-bis(1-benzimidazolyl)-2,4-hexadiyne (5) have beenpreparedby a novel method that consists in refluxing excess imidazole and benzimidazole with 2,4-hexadiyne-1,6-diol bis(p-toluenesulfonate),pTS (3). This procedure is a viable alternative to the widely used Hay coupling protocol in case the target diyne possesses substituents capable of deactivating the copper catalyst by complexation. Diyne1crystallizes as a hydrate,1?H2O(2). For this compound, water is essential toachieve a crystalline material, and attempts to obtain crystals without included solvent were unsuccessful. In the structure of2, the organic fragments organize around the water molecule and interact with it through a dense network of hydrogen bonds. The CMC-CMC moieties are not oriented suitably for topochemical polymerization, and when trying to alter the organizationof the crystal by heating so as to induce polymerization, water is lost in an abrupt fashion that leads to instantaneous decomposition into polyaromatic-like species. Similar results were observed when water was removedin vacuo at room temperature. The benzimidazole-containing compound can be crystallized with water molecules (4)orwithout(5). X-ray crystallography shows that the structure of 5is organized by numerous C-H...N, C-H...p,andimidazolyl...imidazolyl p-p interactions. The diacetylene molecules almost have the right arrangement for topochemical polymerization, withpossibly reactingCMC-CMC fragments not beingparallel, a rare situation indiacetylene chemistry. Yet, experiments showthat topochemical polymerizationdoes not occur. Incorporationofwater in the lattice of5leads toa solvate that is topochemically reactive. Unlike2, however, water molecules in 4are not isolated but are organized as ribbons. Spectroscopic characterization of the polymer of4indicates that it is a blue phase polymer, with water coordinated to it. This study shows that it is possible to use water, and more generally solvent molecules, to transform a nonreactive diacetylene into a reactive one, even though this approach is less predictable than the cocrystal approach developed by Fowler, Lauher, and Goroff. The solvate approach is simple to implement, quite versatile because of the large rangeof solvents available, andonedoes not face theproblemof having to remove the host in case one needs to recover the polymer. Previous studies describing a similar approach are scarce.
Au cours de ce travail, nous avons effectué une étude méthodologique pour la préparation de banques de triazoles, en utilisant la réaction de la chimie " clic ". Ces études ont démontré que la réaction entre un alcyne vrai activé et un azoture est possible dans les conditions sans solvant et sans catalyseur pour conduire un mélange d'isomères 1,4 et 1,5 avec un rendement moyen de 76%. Nous avons remarqué que l'addition des métaux (SiO2, MgCl2, Al2O3, FeCl3 et CuCl2) permettait d'améliorer les rendements des réactions, et on a observé que la silice est la meilleur catalyseur, alors que la catalyse au cuivre (I) donne une sélectivité complète pour l'isomère 1,4. Ce résultat est bien confirmé par l'étude de la régiosélectivité qui montre que les molécules contenant deux types d'alcynes (activé et non activé) peuvent êtres fonctionnalisés séquentiellement et sélectivement. Nous avons aussi préparé les bis-triazoles en deux étapes : la première sur l'alcyne activé sans catalyseur et la deuxième étape se fait sur l'alcyne non activé par catalyse au cuivre (I), ce qui permet de dire que les alcynes terminaux portant un groupement carbonyle en de la triple liaison sont beaucoup plus réactifs.Nous avons également pu étendre l'application de la catalyse supportée dans la réaction de Huisgen dans les domaines de la synthèse de dérivés de produits naturels et d'éthers couronne. En utilisant la synthèse classique et en flux continu, nous avons pu préparer des structures originales dérivées de l'acide quinique porteuse de cycles triazoliques. Ces composés seront testés pour leur activité biologique. Nous avons également entrepris la synthèse de dérivés nouveaux d'éthers couronnes azotes afin d'incorporer à ces structures des bras contenant un ou deux noyaux triazoles. L'obtention de ces substances permettra d'ouvrir l'étude de leur propriétés complexantes dans l'avenir
We present a mathematical study of the order book as a multidimensional continuous- time Markov chain where the order flow is modeled by independent Poisson processes. Our aim is to bridge the gap between the microscopic description of price formation (agent- based modeling), and the Stochastic Differential Equations approach used classically to describe price evolution at macroscopic time scales. To do this, we rely on the theory of infinitesimal generators and Foster-Lyapunov stability criteria for Markov chains. We motivate our approach using an elementary example where the spread is kept constant ("perfect market making"). Then we compute the infinitesimal generator associated with the order book in a general setting, and link the price dynamics to the instantaneous state of the order book. In the last section, we prove that the order book is ergodic - in particular it has a stationary distribution - that it converges to its stationary state exponentially fast, and that the large-scale limit of the price process is a Brownian motion.
In this paper, we consider a discrete time economy where we assume that the short term interest rate follows a quadratic term structure of a regime switching asset process. The possible non-linear structure and the fact that the interest rate can have different economic or financial trends justify the interest of Regime Switching Quadratic Term Structure Model (RS-QTSM). Indeed, this regime switching process depends on the values of a Markov chain with a time dependent transition probability matrix which can well captures the different states (regimes) of the economy. We prove that under this modelling that the conditional zero coupon bond price admits also a quadratic term structure. Moreover, the stochastic coefficients which appear in this decomposition satisfy an explicit system of coupled stochastic backward recursions.
In this note, we cast a Hawkes process-based order book model into a markovian setting and; using techniques from the theory of Markov chains and stochastic stability, show that the order book is stable and leads to a diffusive price limit at large time scales.
A standard approach for large scale image classification involves high dimensional features and Stochastic Gradient Descent algorithm (SGD) for the minimization of classical Hinge Loss in the primal space. Although complexity of Stochastic Gradient Descent is linear with the number of samples these method suffers from slow convergence. In order to cope with this issue, we propose here a Stochastic Low-Rank Newton Descent SLND for minimization of any calibrated loss in the primal space. SLND approximates the inverse Hessian by the best low-rank approximation according to squared Frobenius norm. We provide core optimization for fast convergence. Theoretically speaking, we show explicit convergence rates of the algorithm using these calibrated losses, which in addition provide working sets of parameters for experiments. Experiments are provided on the SUN, Caltech256 and ImageNet databases, with simple, uniform and efficient ways to tune remaining SLND parameters. On each of these databases, SLND challenges the accuracy of SGD with a speed of convergence faster by order of magnitude.
A connected graph G with order n >= 1 is said to be recursively arbitrarily partitionable (R-AP for short) if either it is isomorphic to K_1, or for every sequence (n_1, ..., n_p) of positive integers summing up to n there exists a partition (V_1, ..., V_p) of V(G) such that each V_i induces a connected R-AP subgraph of G on n_i vertices. Since previous investigations, it is believed that a R-AP graph should be "almost traceable" somehow. We first show that the longest path of a R-AP graph on n vertices is not constantly lower than n for every n. This is done by exhibiting a graph family C such that, for every positive constant c >= 1, there is a R-AP graph in C that has arbitrary order n and whose longest path has order n-c. We then investigate the largest positive constant c' < 1 such that every R-AP graph on n vertices has its longest path passing through n.c' vertices. In particular, we show that c' <= 2/3. This result also holds for R-AP graphs with arbitrary connectivity.
The number of available genomic sequences is growing very fast, due to the development of massive sequencing techniques. Sequence identification is needed and contributes to the assessment of gene and species evolutionary relationships. Automated bioinformatics tools are thus necessary to carry out these identification operations in an accurate and fast way. We developed HoSeqI (Homologous Sequence Identification), a software environment allowing this kind of automated sequence identification using homologous gene family databases. HoSeqI is accessible through a Web interface (http://pbil.univ-lyon1.fr/software/HoSeqI/) allowing to identify one or several sequences and to visualize resulting alignments and phylogenetic trees. We also implemented another application, MultiHoSeqI, to quickly add a large set of sequences to a family database in order to identify them, to update the database, or to help automatic genome annotation. Lately, we developed an application, ChiSeqI (Chimeric Sequence Identification), to automate the processes of identification of bacterial 16S ribosomal RNA sequences and of detection of chimeric sequences.
We discuss in this paper phase-field approximations of the Willmore functional and the associated L2-flow. After recollecting known results on the approximation of the Willmore energy and its L1-relaxation, we derive the expression of the flows associated with various approximations, and we show their behavior by formal arguments based on matched asymptotic expansions. We introduce an accurate numerical scheme, whose local convergence can be proved, to describe with more details the behavior of two flows, the classical and the flow associated with an approximation model due to Mugnai. We propose a series of numerical simulations in 2D and 3D to illustrate their behavior in both smooth and singular situations.
In this paper we investigate the regularity properties of weighted Bergman projections for smoothly bounded pseudo-convex domains of finite type in $\mathbb{C}^{n}$. The main result is obtained for weights equal to a non negative rational power of the absolute value of a special defining function $\rho$ of the domain: we prove (weighted) Sobolev-$L^{p}$ and Lipchitz estimates for domains in $\mathbb{C}^{2}$ (or, more generally, for domains having a Levi form of rank $\geq n-2$ and for ''decoupled'' domains) and for convex domains. In particular, for these defining functions, we generalize results obtained by A. Bonami \& S. Grellier and D. C. Chang \& B. Q. Li. We also obtain a general (weighted) Sobolev-$L^{2}$ estimate.
We construct new families of elliptic curves over \(\FF_{p^2}\) with efficiently computable endomorphisms, which can be used to accelerate elliptic curve-based cryptosystems in the same way as Gallant--Lambert--Vanstone (GLV) and Galbraith--Lin--Scott (GLS) endomorphisms. Our construction is based on reducing \(\QQ\)-curves---curves over quadratic number fields without complex multiplication, but with isogenies to their Galois conjugates---modulo inert primes. As a first application of the general theory we construct, for every \(p > 3\), two one-parameter families of elliptic curves over \(\FF_{p^2}\) equipped with endomorphisms that are faster than doubling. Like GLS (which appears as a degenerate case of our construction), we offer the advantage over GLV of selecting from a much wider range of curves, and thus finding secure group orders when \(p\) is fixed. Unlike GLS, we also offer the possibility of constructing twist-secure curves. Among our examples are prime-order curves equipped with fast endomorphisms, with almost-prime-order twists, over \(\FF_{p^2}\) for \(p = 2^{127}-1\) and \(p = 2^{255}-19\).
Zirconium alloy tubing is used in pressurized water nuclear reactors in order to prevent fissile material from leaking into the coolant. It can be the first safety wall of nuclear fuel, and is submitted to complex thermomechanical loadings. In consequence, new Nb-modified alloys, such as the M5 alloy, and fine numerical models are being developed to guarantee a better and longer mechanical integrity of these tubes. To identify the physical mechanisms that could be considered in such models, an experimental approach, combining creep tests with electron backscattered diffraction and Transmission electron microscopy investigations, was carried out. Tubular specimens were submitted to multiaxial creep tests at a temperature of 673 K. Seven ratios between the axial and hoop applied stresses were investigated. It enabled a macroscopic evidence of the creep anisotropy. Besides, EBSD analyses on a mesoscopic- sized non deformed area led to the characterization of the variation of the average Schmid factor with the direction of loading. Finally,TEM observations were done on seven crept samples, corresponding to the seven directions of loading tested mechanically. The variations of the different parameters investigated (activated slip systems, dislocation densities, curvatures of the dislocations) can be seen as the effects of the creep anisotropy at a microscopic scale. The correlation between results is then discussed in a multiscale frame.
The LHCb experiment is a specialized experiment for B and D physics at the CERN LHC. The layout of the experiment and the various components are described, with an overview of their performance. Global running conditions and performance are also shown. The motivation for the foreseen detector upgrade is presented, together with the proposed new detectors, to be installed during Long Shutdown 2, in 2018.
The W mass is a crucial parameter in the Standard Model (SM) of particle physics, providing constraints on the mass of the Higgs boson as well as on new physics models via quantum loop corrections. On the other hand, any deviation of the triple gauge boson couplings (TGC) from their values predicted by the SM would be also an indication for new physics. We present recent measurements on W boson mass and searches for anomalous TGC (aTGC) in Wγ, Zγ, WW, WZ and ZZ at Fermilab Tevatron both by CDF and DØ Collaborations. The CDF Collaboration has measured the W boson mass using data corresponding to 2.2 fb−1 of integrated luminosity. The measurement, performed using electron and muon decays of W boson, yields a mass of MW = 80387 ± 19 MeV. The DØ Collaboration has measured MW = 80367 ± 26 MeV with data corresponding to 4.3 fb−1 of integrated luminosity in the channel W → ev. The combination with an earlier DØ result, using independant data sample at 1 fb−1 of integrated luminosity, yields MW = 80375 ± 23 MeV. The limits on anomalous TGCs parameters are consistent with the SM expectations.
Climate variability and climate change induce important intra- and inter-annual variability of precipitation that significantly alters the hydrologic cycle. The surface water budgets and the plant or ecosystem water use efficiency (WUE) are in turn modified. Obtaining greater insight into how climatic variability and agricultural practices affect water budgets and regarding their components in croplands is, thus, important for adapting crop management and limiting water losses. Therefore, the principal objectives of this study are: (1) to assess the contribution of different components to the agro-ecosystem water budget and (2) to evaluate how agricultural practices and climate modify the components of the surface water budget. To achieve these goals, we tested a new method for partitioning evapotranspiration (ETR), measured by means of an eddy-covariance method, into soil evaporation (E) and plant transpiration (TR) based on marginal distribution sampling (MDS). The partitioning method proposed requires continuous flux recording and measurements of soil temperature and humidity close to the surface, global radiation above the canopy and assessment of leaf area index dynamics. This method is well suited for crops because it requires a dataset including long bare-soil periods alternating with vegetated periods for accurate partitioning estimation. We compared these estimations with calibrated simulations of the ICARE-SVAT double source mechanistic model. The results showed good agreement between the two partitioning methods, demonstrating that MDS is a convenient, simple and robust tool for estimating E with reasonable associated uncertainties. During the growing season, the proportion of E in ETR was approximately one-third and varied mainly with crop leaf area. When calculated on an annual time scale, the proportion of E in ETR reached more than 50%, depending on the crop leaf area and on the duration and distribution of bare soil within the year.
The tectonosedimentary development of the South Atlantic is compared with the Central Atlantic margins, which are associated with major episodes of magmatism during the Mesozoic continental break-up. Subsequently, the Cenozoic break-up in the North Atlantic led to the formation of the volcanic Norwegian-Greenland conjugate margins. The DSDP boreholes in the magma-poor Iberian-Newfoundland margins have confirmed the occurrence of exhumed mantle at the ocean - continent transition. This possibility has been suggested for the South Atlantic margins, but still lacks confirmation from drilling. The Red Sea and the Gulf of Aden may be considered as natural laboratories to study the break- up processes and formation of divergent continental margins. Using key geological and geophysi- cal data, we compare some of the structures observed in incipient stages of basin formation between the African and the Arabian plates with the structures observed in older sedimentary basins associated with the Gondwana break-up. We also analyse deep seismic reflection profiles and potential field data at the continent-ocean boundary of these conjugate margins, using palin- spastic reconstructions to define the corresponding seismic pairs. We conclude that the Red Sea and the Gulf of Aden display remarkable differences to the Iberian-Newfoundland margins, and notable similarities with the South Atlantic margins.
We analyse P-wave receiver functions across the western Gulf of Aden and southern Red Sea continental margins in Western Yemen to constrain crustal thickness, internal crustal structure and the bulk seismic velocity characteristics in order to address the role of magmatism, faulting and mechanical crustal thinning during continental breakup. We analyse teleseismic data from 21 stations forming the temporary Young Conjugate Margins Laboratory (YOCMAL) network together with GFZ and Yemeni permanent stations. Analysis of computed receiver functions shows that (1) the thickness of unextended crust on the Yemen plateau is ∼35km; (2) this thins to ∼22km in coastal areas and reaches less than 14km on the Red Sea coast, where presence of a high-velocity lower crust is evident. The average Vp/Vs ratio for the western Yemen Plateau is 1.79, increasing to ∼1.92 near the Red Sea coast and decreasing to 1.68 for those stations located on or near the granitic rocks. Thinning of the crust, and by inference extension, occurs over a ∼130-km-wide transition zone from the Red Sea and Gulf of Aden coasts to the edges of the Yemen plateau. Thinning of continental crust is particularly localized in a <30-km-wide zone near the coastline, spatially co-incident with addition of magmatic underplate to the lower crust, above which on the surface we observe the presence of seaward dipping reflectors (SDRs) and thickened Oligo-Miocene syn-rift basaltic flows. Our results strongly suggest the presence of high-velocity mafic intrusions in the lower crust, which are likely either synrift magmatic intrusion into continental lower crust or alternatively depleted upper mantle underplated to the base of the crust during the eruption of the SDRs. Our results also point towards a regional breakup history in which the onset of rifting was synchronous along the western Gulf of Aden and southern Red Sea volcanic margins followed by a second phase of extension along the Red Sea margin.
An efficient numerical method to compute solitary wave solutions to the free surface Euler equations is reported. It is based on the conformal mapping technique combined with an efficient Fourier pseudo-spectral method. The resulting nonlinear equation is solved via the Petviashvili iterative scheme. The computational results are compared to some existing approaches, such as the Tanaka method and Fenton's high-order asymptotic expansion. Several important integral quantities are numerically computed for a large range of amplitudes. The integral representation of the velocity and acceleration fields in the bulk of the fluid is also provided.
An improved Lozi function with alternate coefficients has been proposed. The modifications in the model allow to remove the holes in the attractor which are not desirable, but appeared in the previous Lozi function; in this way, an everywhere dense attractor can be obtained. Moreover, the strong sensitivity to the type of binarisation (conversion of real values to 0 and 1) has been demonstrated; this conversion to binary numbers is instrumental to apply the NIST tests for randomness. The results have been validated and compared via NIST tests, for the different methods of quantization. Finally, is has been verfied that the multi-random properties of the output signal have been improved thanks to the following strategies : under-sampling of the output signal, and the system order increasing. Keywords. Nonlinear dynamical system, ring-coupled map, Lozi function, NIST tests, discrete-time map, dense chaotic attractor, pseudo random number generator 1 I
The extreme characteristics of long wave run-up are studied in this paper. First we give a brief overview of the existing theory which is mainly based on the hodograph transformation (Carrier & Greenspan, 1958). Then, using numerical simulations, we build on the work of Stefanakis et al. (2011) for an infinite sloping beach and we find that resonant run-up amplification of monochromatic waves is robust to spectral perturbations of the incoming wave and resonant regimes do exist for certain values of the frequency. In the setting of a finite beach attached to a constant depth region, resonance can only be observed when the incoming wavelength is larger than the distance from the undisturbed shoreline to the seaward boundary. Wavefront steepness is also found to play a role in wave run-up, with steeper waves reaching higher run-up values.
Fifty years ago, FitzHugh introduced a phase portrait that became famous for a twofold reason: it captured in a physiological way the qualitative behavior of Hodgkin-Huxley model and it revealed the power of simple dynamical models to unfold complex firing patterns. To date, in spite of the enormous progresses in qualitative and quantitative neural modeling, this phase portrait has remained a core picture of neuronal excitability. Yet, a major difference between the neurophysiology of 1961 and of 2011 is the recognition of the prominent role of calcium channels in firing mechanisms. We show that including this extra current in Hodgkin-Huxley dynamics leads to a revision of FitzHugh-Nagumo phase portrait that affects in a fundamental way the reduced modeling of neural excitability. The revisited model considerably enlarges the modeling power of the original one. In particular, it captures essential electrophysiological signatures that otherwise require non-physiological alteration or considerable complexification of the classical model. As a basic illustration, the new model is shown to highlight a core dynamical mechanism by which calcium channels control the two distinct firing modes of thalamocortical neurons.
This paper studies the excitability properties of a generalized FitzHugh-Nagumo model. The model differs from the classical FitzHugh-Nagumo model in that it accounts for the effect of cooperative gating variables such as activation of calcium currents. Excitability is explored by unfolding a pitchfork bifurcation that is shown to organize five different types of excitability. In addition to the three classical types of neuronal excitability, two novel types are described and distinctly associated to the presence of cooperative variables.
Les tâches d'empan de mémoire de travail sont des tâches dans lesquelles des items doivent être maintenus en mémoire à court terme pendant qu'un traitement concurrent est effectué. Le but de la présente étude était de déterminer si, comme le soutient le modèle de partage temporel des ressources (Barrouillet, Bernardin, & Camos, 2004), les traitements gênent le maintien parce que les deux composantes entrent en compétition pour des processus communs ou plus simplement parce que les stratégies de maintien des items à rappeler sont perturbées par l'intrusion de l'information à traiter simultanément. Quatre-vingt sujets adultes étaient soumis à une tâche d'empan où ils devaient maintenir des lettres en même temps qu'ils devaient juger soit de la parité soit de la position spatiale de nombre présentés successivement à l'écran. Par ailleurs, ces nombres apparaissaient à un rythme régulier et donc prévisible ou bien aléatoire. Conformément à nos attentes, et contrairement à l'hypothèse d'une perturbation des stratégies de maintien, les jugements de parité qui nécessitent des récupérations en mémoire entraînaient de plus faibles empans que la tâche spatiale qui ne requiert qu'une sélection de réponse alors que le rythme de réalisation de la tâche secondaire n'avait pas d'effet sur les empans.
La contamination de l'air par les produits phytosanitaires peut induire des risques importants pour la santé humaine. Les techniques de pulvérisation induisent une contamination de l'air, notamment en production fruitière. En 2001, des expérimentations ont montré des niveaux importants de contamination en aval d'une parcelle de vigne pendant et après la période de pulvérisation. A l'échelle de l'homme l'exposition est toutefois difficile à mesurer à cause de la grande variabilité spatio-temporelle de la contamination. Pour pallier cette difficulté, les travaux de recherche portent sur le couplage de données de simulation et de mesure pour évaluer avec précision la qualité de l'air. Les expérimentation sont conduite en laboratoire ou dans les champs. L'objectif est de développer des méthodologies d'échantillonnage et d'analyse adaptées à la protection de populations afin d'améliorer les méthodes de pulavrisation. / Air contamination by Plant Protection Products (PPPs) carries significant risks for human health. Crop protection spraying induces air contamination, mainly in fruit production. In 2001, observations showed important transfers during and after spraying (direct losses vs. volatilization from soil and crop), downwind a productive vineyard. At the human scale the resulting exposure is difficult to measure because the PPPS concentration vary greatly in space and time. In consequence, researches are focused on coupling simulation tools and data to estimate properly the air contamination. Experimentations are conducted at fieldscale and labscale. The objective is to improve the methodology on air sampling and to develop analysis tools dedicated to population protection and spraying optimisation recommendation.
Marine Synechococcus undergo a wide range of environmental stressors, especially high and variable irradiance, which may induce oxidative stress through the generation of reactive oxygen species (ROS). While light and ROS could act synergistically on the impairment of photosynthesis, inducing photodamage and inhibiting photosystem II repair, acclimation to high irradiance is also thought to confer resistance to other stressors. To identify the respective roles of light and ROS in the photoinhibition process and detect a possible light-driven tolerance to oxidative stress, we compared the photophysiological and transcriptomic responses of Synechococcus sp. WH7803 acclimated to low light (LL) or high light (HL) to oxidative stress, induced by hydrogen peroxide (H₂O₂) or methylviologen. While photosynthetic activity was much more affected in HL than in LL cells, only HL cells were able to recover growth and photosynthesis after the addition of 25 μM H₂O₂. Depending upon light conditions and H₂O₂ concentration, the latter oxidizing agent induced photosystem II inactivation through both direct damage to the reaction centers and inhibition of its repair cycle. Although the global transcriptome response appeared similar in LL and HL cells, some processes were specifically induced in HL cells that seemingly helped them withstand oxidative stress, including enhancement of photoprotection and ROS detoxification, repair of ROS-driven damage, and regulation of redox state. Detection of putative LexA binding sites allowed the identification of the putative LexA regulon, which was down-regulated in HL compared with LL cells but up-regulated by oxidative stress under both growth irradiances.
Chaque année du début du prin - temps jusqu'aux premiers jours de l'automne, des milliards d'abeilles sortent de leurs ruches et partent visiter les fleurs des paysages environnants. Elles y trouvent nectars et pollens, éléments essentiels à la base de leur alimentation. C'est par cette intense activité de butinage que l'abeille domestique participe activement à la pollinisation des plantes sauvages et cultivées. Son influence directe sur la qualité et la quantité des récoltes ainsi que sur le maintien de la biodiversité florale est aujourd'hui largement validée et souligne le rôle prépondérant des abeilles (sauvages et domestiques) dans le fonctionnement des écosystèmes. En France, les abeilles domestiques, Apis mellifera (Hymenoptera: Apidae), sont l'outil de travail d'environ 70 000 apiculteurs professionnels et amateurs qui tirent bénéfice des labeurs de cet hyménoptère (environ 20 000 tonnes de miel récoltées en France en 2009).
Ce modeste article vise à donner quelques pistes pour la recherche diachronique du verbe basque. Il s'inscrit dans le cadre d'un projet de recherche de thèse de doctorat, et loin de prétendre donner la clé de l'évolution du verbe basque, il espère offrir quelques remarques de morphologie et syntaxe qui selon nous ont leur importance au moment de faire l'histoire des formes verbales. Les verbes périphrastiques ont attiré l'attention de nombreux bascologues. Tout d'abord Lafon (1943) consacra le deuxième tome de sa thèse aux formes périphrastiques des textes du XVIème siècle. Après lui, d'autres comme Yrizar en ont répertorié les quelques nuances morphologiques et les nombreuses nuances phonétiques que l'on retrouve d'un dialecte à l'autre. Dans ce court article nous n'entendons pas traiter la composition phonétique des formes périphrastiques, mais plutôt leur structure morpho-syntaxique. Pour cela, nous allons étudier les trois périphrases principales des XVIème et XVIIème siècles, à savoir, (i) racine verbale + auxiliaires *edin, *ezan, *iro, egin, (ii) nom verbal à l'inessif + auxiliaires izan, *edun, (iii) participe + auxiliaires izan, *edun; et les classer selon leurs structure, emploi(s), niveau de grammaticalisation à cette époque. Comme nous le verrons, il a souvent été pensé que la périphrase verbale du basque est attribuable au contact avec les langues romanes. Après l'étude de chacune de ces trois périphrases, nous verrons que parmi elles, seule une, a des parallèles dans ces langues, et que les deux autres semblent être issues d'une évolution interne au basque. Nous tenterons enfin de proposer une chronologie relative de ces périphrases, mais aussi de celles-ci par rapport aux formes simples, ou fortes.
Les récents épisodes de turbulence financière sont venus remettre en cause la précision des mesures classiques de risque pour évaluer les risques extrêmes. Ces mesures de risques, telles que la VaR, sont devenues incontournables dans la gestion des risques et l'allocation d'actifs (Basak et Shapiro [2001] ; Monfort [2008]). Nous estimons le risque de modèle des mesures de risque et nous évaluons son impact sur l'allocation d'actifs optimale à différents horizons. Nos résultats montrent, sur des données longues américaines, une relation en U-inversé entre notre mesure du risque de modèle sur les VaR historiques et l'horizon de l'agent représentatif, qui impacte sensiblement son allocation optimale.
Nous décrivons une méthode pour comparer des techniques de diagnostic des connaissances en fonction de leur impact sur les prises de décision de l'EIAH. À partir de traces d'apprenants, nous utilisons une méthode de classification automatique pour prédire le résultat (succès ou échec) d'une aide donnée par l'EIAH, en prenant en considération des informations sur l'apprenant, la tâche et l'état des connaissances de l'apprenant. Il en résulte une stratégie d'aide apprise automatiquement et permettant de sélectionner dans une situation donnée l'aide ayant la probabilité la plus élevée de succès. Le moyen usuel mais coûteux d'évaluer une telle stratégie d'aide est de l'implémenter et de la tester sur de nouveaux apprenants, ce qui nécessite du temps et des moyens. Nous utilisons plutôt des données déjà collectées, où les aides sont données aléatoirement aux apprenants, pour simuler l'impact d'une stratégie d'aide. Nous comparons ensuite différentes stratégies d'aide basées sur différentes techniques de diagnostic. Nous avons testé notre méthode en utilisant les données du Reading Tutor (projet LISTEN), destiné à l'apprentissage de la lecture. Nous rapportons la précision de la prédiction de quatre techniques de diagnostic en validation croisée, puis comparons l'impact des stratégies d'aide basées sur ces techniques. Notre méthode fournit une métrique pour comparer différentes techniques de diagnostic fondées sur leur utilité pour les prises de décision de l'EIAH.
Zirconium alloy tubing is used in pressurized water nuclear reactors in order to prevent fissile material from leaking into the coolant. It can be the first safety wall of nuclear fuel, and is submitted to complex thermomechanical loadings. In consequence, new Nb-modified alloys, such as the M5 alloy, and fine numerical models are being developed to guarantee a better and longer mechanical integrity of these tubes. To identify the physical mechanisms that could be considered in such models, an experimental approach, combining creep tests with electron backscattered diffraction and Transmission electron microscopy investigations, was carried out. Tubular specimens were submitted to multiaxial creep tests at a temperature of 673 K. Seven ratios between the axial and hoop applied stresses were investigated. It enabled a macroscopic evidence of the creep anisotropy. Besides, EBSD analyses on a mesoscopic- sized non deformed area led to the characterization of the variation of the average Schmid factor with the direction of loading. Finally,TEM observations were done on seven crept samples, corresponding to the seven directions of loading tested mechanically. The variations of the different parameters investigated (activated slip systems, dislocation densities, curvatures of the dislocations) can be seen as the effects of the creep anisotropy at a microscopic scale. The correlation between results is then discussed in a multiscale frame.
For turbo code with coding rate close to one, the high puncturing rate induces long sequences of trellis without redundancy bit. A simplification technique to compute the final state of a sequence of Redundancy Free Trellis Stage (RFTS) is presented. It compresses a sequence of RFTS of length $N$ into a sequence of RFTS of length $m-1 + (N \mod (m-1))$, where $m$ is the number of states of the trellis. The computation is reduced accordingly.
L'article présente un modèle de simulation du comportement transitoire d'un système insulaire incluant différenrs moyens de production : groupes hydrauliques, thermiques, diesel, turbines à gaz et éoliennes. L'objectif est d'analyser l'impact d'une intégration élevée des énergies renouvelables et l'intéraction entre les groupes hydrauliques (qui ont un comportement dynamique particulier) et les éoliennes.
n.a
N(6)-threonylcarbamoyladenosine (t(6)A) is a modified nucleotide found in all transfer RNAs (tRNAs) decoding codons starting with adenosine. Its role is to facilitate codon-anticodon pairing and to prevent frameshifting during protein synthesis. Genetic studies demonstrated that two universal proteins, Kae1/YgjD and Sua5/YrdC, are necessary for t(6)A synthesis in Saccharomyces cerevisiae and Escherichia coli. In Archaea and Eukarya, Kae1 is part of a conserved protein complex named kinase, endopeptidase and other proteins of small size (KEOPS), together with three proteins that have no bacterial homologues. Here, we reconstituted for the first time an in vitro system for t(6)A modification in Archaea and Eukarya, using purified KEOPS and Sua5. We demonstrated binding of tRNAs to archaeal KEOPS and detected two distinct adenosine triphosphate (ATP)-dependent steps occurring in the course of the synthesis. Our data, together with recent reconstitution of an in vitro bacterial system, indicated that t(6)A cannot be catalysed by Sua5/YrdC and Kae1/YgjD alone but requires accessory proteins that are not universal. Remarkably, we observed interdomain complementation when bacterial, archaeal and eukaryotic proteins were combined in vitro, suggesting a conserved catalytic mechanism for the biosynthesis of t(6)A in nature. These findings shed light on the reaction mechanism of t(6)A synthesis and evolution of molecular systems that promote translation fidelity in present-day cells.
Structural refinement of proteins involves the minimization of a target function that combines X-ray data with a set of restraints enforcing stereochemistry and packing. Electrostatic interactions are not ordinarily included in the target function, partly because they cannot be calculated reliably without a description of dielectric screening by solvent in the crystal. With the recent development of accurate implicit solvent models to describe this screening, the question arises as to whether a more detailed target function including electrostatic and solvation terms can yield more accurate structures or somewhat different structures of equivalent accuracy. The Generalized Born (GB) model is one such model that describes the solvent as a dielectric continuum, taking into account its heterogeneous distribution within the crystal. It is used here for X-ray refinements of three protein structures with experimental diffraction data to 2.4, 2.9 and 3.2 A, respectively. In each case, a higher resolution structure is available for comparison. The new target function includes stereochemical restraints, van der Waals, Coulomb and solvation interactions, along with the usual X-ray pseudo-energy term, which employs the likelihood estimator of Pannu and Read. Multiple simulated-annealing refinements were performed in torsion-angle space with a conventional target function and the new GB target function, yielding ensembles of refined structures. The new target function yields structures of similar accuracy, as measured by the free R factor, map/model correlations and deviations from the high-resolution structures. About 10% of side-chain conformations differ between the two sets of refinements, in the sense that the two ensembles of conformations do not completely overlap. Over 75% of the differences correspond to surface side chains. For one of the proteins, the GB set has a greater dispersion, indicating that for this case the conventional target function overestimates the true precision. As GB parameterization continues to improve, we expect that this approach will become increasingly useful.
In approachability with full monitoring there are two types of conditions that are known to be equivalent for convex sets: a primal and a dual condition. The primal one is of the form: a set C is approachable if and only all containing half-spaces are approachable in the one-shot game; while the dual one is of the form: a convex set C is approachable if and only if it intersects all payoff sets of a certain form. We consider approachability in games with partial monitoring. In previous works (Perchet 2011; Mannor et al. 2011) we provided a dual characterization of approachable convex sets; we also exhibited efficient strategies in the case where C is a polytope. In this paper we provide primal conditions on a convex set to be approachable with partial monitoring. They depend on a modified reward function and lead to approachability strategies, based on modified payoff functions, that proceed by projections similarly to Blackwell's (1956) strategy; this is in contrast with previously studied strategies in this context that relied mostly on the signaling structure and aimed at estimating well the distributions of the signals received. Our results generalize classical results by Kohlberg 1975 (see also Mertens et al. 1994) and apply to games with arbitrary signaling structure as well as to arbitrary convex sets.
Présentation du calcul de la distance intertextuelle et de deux méthodes de classification (classification hiérarchique ascendante, analyse arborée). Caractérisation du vocabulaire spécifique des différentes classes. Application à un groupe d'entretiens sur le confort électrique.
We consider supervised learning problems within the positive-definite kernel framework, such as kernel ridge regression, kernel logistic regression or the support vector machine. With kernels leading to infinite-dimensional feature spaces, a common practical limiting difficulty is the necessity of computing the kernel matrix, which most frequently leads to algorithms with running time at least quadratic in the number of observations n, i.e., O(n^2). Low-rank approximations of the kernel matrix are often considered as they allow the reduction of running time complexities to O(p^2 n), where p is the rank of the approximation. The practicality of such methods thus depends on the required rank p. In this paper, we show that in the context of kernel ridge regression, for approximations based on a random subset of columns of the original kernel matrix, the rank p may be chosen to be linear in the degrees of freedom associated with the problem, a quantity which is classically used in the statistical analysis of such methods, and is often seen as the implicit number of parameters of non-parametric estimators. This result enables simple algorithms that have sub-quadratic running time complexity, but provably exhibit the same predictive performance than existing algorithms, for any given problem instance, and not only for worst-case situations.
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