%0 Journal Article
%T Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study
%+ Institut des Neurosciences de Montpellier (INM)
%+ Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO)
%+ Laboratoire d'Imagerie et de Spectroscopie (LRMN)
%+ Institut d’Imagerie Fonctionnelle Humaine [CHU Montpellier] (I2FH)
%+ Centre d'Acquisition et de Traitement des Images [Paris] = CATI Multicenter Neuroimaging Platform (CATI)
%+ Institut du Cerveau = Paris Brain Institute (ICM)
%+ Building large instruments for neuroimaging: from population imaging to ultra-high magnetic fields (BAOBAB)
%+ Euromov (EuroMov)
%+ Laboratoire Charles Coulomb (L2C)
%+ Institut de génétique humaine (IGH)
%+ Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP)
%+ Equipe Vieillissement (CERPOP)
%+ Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
%+ Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC)
%+ Université de Montpellier (UM)
%+ Département de Neuroradiologie[Montpellier]
%A Perus, Lisa
%A Mangin, Jean-François
%A Deverdun, Jérémy
%A Gutierrez, Laure-Anne
%A Gourieux, Emmanuelle
%A Fischer, Clara
%A van Dokkum, Liesjet
%A Manesco, Clara
%A Busto, Germain
%A Guyonnet, Sophie
%A Vellas, Bruno
%A Gabelle, Audrey
%A Le Bars, Emmanuelle
%< avec comité de lecture
%@ 1663-4365
%J Frontiers in Aging Neuroscience
%I Frontiers
%V 14
%8 2023-01-10
%D 2023
%R 10.3389/fnagi.2022.971220
%M 36705622
%K magnetic resonance imaging (MRI)
%K resting-state functional MRI (rs-fMRI)
%K multidomain intervention
%K exercise
%K cognitive training
%K omega-3 fatty acids
%Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles
%X Introduction The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood and may involve brain reserve and adaptability of brain functional connectivity (FC). Methods To determine the effect of multidomain interventions (involving physical activity, cognitive training, nutritional counseling alone or in combination with omega-3 fatty acid supplementation and vs. a placebo) on the brain, longitudinal FC changes were assessed after 36 months of intervention on 100 older adults (above 70 year-old) with subjective cognitive complaints. Results No global change in FC was detected after uni or multidomain preventive interventions. However, an effect of omega-3 fatty acid supplementation dependent on cognitive decline status was underlined for frontoparietal, salience, visual and sensorimotor networks FC. These findings were independent of the cortical thickness and vascular burden. Discussion These results emphasize the importance of patient stratification, based on risk factors, for preventive interventions.
%G English
%2 https://hal.science/hal-04492076/document
%2 https://hal.science/hal-04492076/file/fnagi-14-971220.pdf
%L hal-04492076
%U https://hal.science/hal-04492076
%~ CEA
%~ UNIV-TLSE3
%~ CNRS
%~ UNIV-MONTP1
%~ APHP
%~ INM
%~ IGH
%~ SANTE_PUB_INSERM
%~ L2C
%~ U1061
%~ ICM
%~ CEA-UPSAY
%~ UNIV-PARIS-SACLAY
%~ BS
%~ UNIV-MONTPELLIER
%~ JOLIOT
%~ CEA-DRF
%~ NEUROSPIN
%~ SORBONNE-UNIVERSITE
%~ SORBONNE-UNIV
%~ SU-MEDECINE
%~ SU-MED
%~ UNIVERSITE-PARIS-SACLAY
%~ SU-TI
%~ ANR
%~ GS-LIFE-SCIENCES-HEALTH
%~ ALLIANCE-SU
%~ UNIV-UT3
%~ UT3-INP
%~ UT3-TOULOUSEINP
%~ UM-2015-2021
%~ UM-EPE
%~ CERPOP
%~ CERPOP-VIEILLISSEMENT