%0 Journal Article %T Insight into tableted pellets by combining X-ray micro-computed tomography and experimental compaction %+ Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM) %+ Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud) %+ Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE) %+ Physique et Mécanique des Milieux Divisés (PMMD) %A Boudina, Imen %A Rondet, Eric %A Nezamabadi, Saeid %A Sharkawi, Tahmer %Z Algerian Ministry of High Education and Scientific Research %< avec comité de lecture %@ 0032-5910 %J Powder Technology %I Elsevier %V 397 %8 2022-01 %D 2022 %R 10.1016/j.powtec.2021.117083 %K Tableting %K Experimental compaction %K Pellet deformation %K X-ray micro computed tomography %Z Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci]Journal articles %X Pellets are spherical agglomerated particles used to produce multiparticulate pharmaceutical dosage forms. This study aims to develop a new approach that evaluates the deformation behavior of pellets under compression, by combining tableting data and compression models with X-ray micro computed tomography (XMT) image analysis. The deformation of Microcrystalline cellulose (MCC) and sugar pellets known to have different deformation behavior under compression was investigated. Compression data and modeling confirmed the plastic and brittle behavior for MCC and sugar pellets respectively. Image analysis of the XMT showed a different evolution of the morphometric parameters: structure thickness diameter (St Th) and volume equivalent sphere diameter (ESDv). The brittle sugar pellets showed a decrease in both ESDv and St Th parameters while plastic MCC pellets showed a decrease in ST Th and a constant ESDv which is coherent with ductile and brittle material deformation. This study shows that XMT can be used as a tool to characterize the mechanical behavior of pellet particles during compression %G English %2 https://hal.inrae.fr/hal-03678035/document %2 https://hal.inrae.fr/hal-03678035/file/Boudina_al_Powder-Tech_2022.pdf %L hal-03678035 %U https://hal.inrae.fr/hal-03678035 %~ IRD %~ CIRAD %~ UNIV-AVIGNON %~ AFRIQ %~ CNRS %~ ENSC-MONTPELLIER %~ ICG %~ IATE %~ QUALISUD %~ LMGC %~ INC-CNRS %~ AGREENIUM %~ CHIMIE %~ UNIV-MONTPELLIER %~ INSTITUT-AGRO-MONTPELLIER %~ INRAE %~ INRAEOCCITANIEMONTPELLIER %~ UM-2015-2021 %~ UM-EPE %~ RESEAU-EAU %~ INSTITUT-AGRO