BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity

Benoit Bailly (1) , Luc Guilpain , Kevin Bouiller (2, 1) , Catherine Chirouze (2, 1) , Melissa N'Debi (3) , Alexandre Soulier (3) , Vanessa Demontant (3) , Jean-Michel Pawlotsky (3) , Christophe Rodriguez (3) , Slim Fourati (3)

1 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
2 LCE - Laboratoire Chrono-environnement (UMR 6249)
3 CHU Henri Mondor [Créteil]

Abstract We report an outbreak of severe acute respiratory syndrome coronavirus 2 501Y.V2 in a nursing home. All nonvaccinated residents (5/5) versus half of those vaccinated with BNT162b2 (13/26) were infected. Two of 13 vaccinated versus 4 of 5 nonvaccinated residents presented severe disease. BNT162b2 did not prevent the outbreak, but reduced transmission and disease severity.

Mots clés: BNT162b2 vaccine; SARS CoV-2; nursing home; outbreak; variant

Domaines: Médecine humaine et pathologie; Microbiologie et Parasitologie

Benoit Bailly, Luc Guilpain, Kevin Bouiller, Catherine Chirouze, Melissa N'Debi, et al.. BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity. Clinical Infectious Diseases, 2021, ⟨10.1093/cid/ciab446⟩. ⟨hal-03364251⟩