Investigating new serological and tissue markers for the follow‐up of patients operated for alveolar echinococcosis

Anne-Pauline Bellanger (1, 2, 3) , Junhua Wang (4) , Houssein Gbaguidi-Haore , Coralie Barrera (2, 3) , Solange Bresson-Hadni (1, 3) , Inti Zlobec (5) , Anja Lachenmayer (6) , Carine Richou (3, 7) , Celia Turco (8) , Bruno Gottstein (4) , Laurence Millon (1, 2, 3) , Guido Beldi (6)

1 Service de parasitologie et mycologie [CHRU de Besançon]
2 LCE - Laboratoire Chrono-environnement (UMR 6249)
3 Department of Parasitology-Mycology, National Reference Centre for Echinococcoses, University Hospital of Besançon, 25030 Besançon, France
4 Institute for Infectious Diseases, Faculty of Medicine, University of Berne, 3001 Berne, Switzerland
5 UNIBE - Universität Bern / University of Bern
6 Department of Visceral and Transplant Surgery
7 Service d'Hépatologie [CHRU Besançon]
8 Service de Chirurgie Digestive [CHRU Besançon]

Alveolar echinococcosis (AE) is characterized by a chronically progressing hepatic injury caused by Echinococcus multilocularis. Surgery presently remains the best curative option. Currently, biological predictive features derived from the resected specimens are not suitable to assess surgery efficacy. The present study was designed to investigate whether a selection of markers measured on the resected specimens exhibits predictive features related to parasite viability, or to a total elimination of the parasite, in addition to serological markers.

Mots clés: CD-3; Em18; PD-L1; follow-up; microarray; serology

Domaines: Santé; Médecine humaine et pathologie

Anne-Pauline Bellanger, Junhua Wang, Houssein Gbaguidi-Haore, Coralie Barrera, Solange Bresson-Hadni, et al.. Investigating new serological and tissue markers for the follow‐up of patients operated for alveolar echinococcosis. Parasite Immunology, 2021, 43 (6), pp.e12827. ⟨10.1111/pim.12827⟩. ⟨hal-03315295⟩