Focus on Multi-targeted Role of Curcumin: a Boon in Therapeutic Paradigm
Résumé
Curcumin is a polyphenolic compound that exhibited good anticancer potential against different types of cancers through its
multi-targeted effect like the termination of cell proliferation, inflammation, angiogenesis, and metastasis, thereby acting as
antiproliferative and cytotoxic in nature. The present review surveys the various drug combination tried with curcumin or its
synthetic analogues and also the mechanism by which curcumin potentiates the effect of almost every drug. In addition, this
article also focuses on aromatherapy which is gaining much popularity in cancer patients. After thoroughly studying several
articles on combination therapy of curcumin through authenticated book chapters, websites, research, and review articles
available at PubMed, ScienceDirect, etc., it has been observed that multi-targeted curcumin possess enormous anticancer
potential and, with whatever drug it is given in combination, has always resulted in enhanced effect with reduced dose as well
as side effects. It is also capable enough in overcoming the problem of chemoresistance. Besides this, aromatherapy also proved
its potency in reducing cancer-related side effects. Combining all the factors together, we can conclude that combination therapy
of drugs with curcumin should be explored extensively. In addition, aromatherapy can be used as an adjuvant or supplementary
therapy to reduce the cancer complications in patients.