Design of new disubstituted imidazo[1,2- b ]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation

Jonathan Elie (1) , Omid Feizbakhsh (2) , Nathalie Desban (2) , Béatrice Josselin (2, 3, 4) , Blandine Baratte (2, 3, 4) , Amandine Bescond (2) , Julien Duez , Xavier Fant , Stéphane Bach (2, 3, 4) , Dominique Marie , Matthieu Place (1) , Sami Ben Salah , Agnes Chartier , Sabine Berteina-Raboin , Apirat Chaikuad , Stefan Knapp , Fabrice Carles (1) , Pascal Bonnet (1) , Frédéric Buron (1) , Sylvain Routier (1) , Sandrine Ruchaud (2)

1 ICOA - Institut de Chimie Organique et Analytique
2 LBI2M - Laboratoire de Biologie Intégrative des Modèles Marins
3 FR2424 - Fédération de recherche de Roscoff
4 SBR - Station biologique de Roscoff = Roscoff Marine Station

Domaines: Sciences du Vivant [q-bio]; Chimie

Jonathan Elie, Omid Feizbakhsh, Nathalie Desban, Béatrice Josselin, Blandine Baratte, et al.. Design of new disubstituted imidazo[1,2- b ]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.1840-1853. ⟨10.1080/14756366.2020.1825408⟩. ⟨hal-03004407⟩