%0 Journal Article
%T DNA-Polymer micelles as nanoparticles with recognition ability
%+ Interactions moléculaires et réactivité chimique et photochimique (IMRCP)
%+ Université Toulouse III - Paul Sabatier (UT3)
%+ Laboratoire Charles Coulomb (L2C)
%+ Laboratoire Léon Brillouin (LLB - UMR 12)
%+ Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
%+ Institut des Technologies Avancées en sciences du Vivant (ITAV)
%+ Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA)
%A Talom, Renee Mayap
%A Fuks, Gad
%A Kaps, Leonard
%A Oberdisse, Julian
%A Cerclier, Christel
%A Gaillard, Cedric
%A Mingotaud, Christophe
%A Gauffre, Fabienne
%Z The authors thank all the present and former collaborators of the project "DNATOOL". We acknowledge the Agence Nationale de la Recherche for funding (program ANR PNANO-07) and the Laboratoire d'Analyse et d'Architecture des Systemes (LAAS-CNRS) for access to Nanoscope 3.
%< avec comité de lecture
%@ 0947-6539
%J Chemistry - A European Journal
%I Wiley-VCH Verlag
%V 17
%N 48
%P 13495 - 13501
%8 2011
%D 2011
%R 10.1002/chem.201101561
%K block copolymers
%K molecular recognition
%K oligonucleotides;
%K surface patterning
%K chemistry
%K multidisciplinary
%K micelles
%Z Life Sciences [q-bio]/Food engineering
%Z Engineering Sciences [physics]/Chemical and Process EngineeringJournal articles
%X The Watson-Crick binding of DNA single strands is a powerful tool for the assembly of nanostructures. Our objective is to develop polymer nanoparticles equipped with DNA strands for surface-patterning applications, taking advantage of the DNA technology, in particular, recognition and reversibility. A hybrid DNA copolymer is synthesized through the conjugation of a ssDNA (22-mer) with a poly(ethylene oxide)-poly(caprolactone) diblock copolymer (PEO-b-PCl). It is shown that, in water, the PEO-b-PCl-ssDNA(22) polymer forms micelles with a PCl hydrophobic core and a hydrophilic corona made of PEO and DNA. The micelles are thoroughly characterized using electron microscopy (TEM and cryoTEM) and small-angle neutron scattering. The binding of these DNA micelles to a surface through DNA recognition is monitored using a quartz crystal microbalance and imaged by atomic force microscopy. The micelles can be released from the surface by a competitive displacement event.
%G English
%L hal-02648183
%U https://hal.inrae.fr/hal-02648183
%~ CEA
%~ UNIV-TLSE3
%~ CNRS
%~ INSA-TOULOUSE
%~ INRA
%~ L2C
%~ INC-CNRS
%~ IRAMIS-LLB
%~ AGREENIUM
%~ MIPS
%~ UNIV-MONTPELLIER
%~ INSA-GROUPE
%~ INRAE
%~ IRAMIS
%~ GS-PHYSIQUE
%~ TOULOUSE-INP
%~ UNIV-UT3
%~ UT3-INP
%~ FEDERATION-FERMAT
%~ UT3-TOULOUSEINP
%~ UM-2015-2021
%~ TEST2-HALCNRS
%~ SOFTMAT