New insights on the supramolecular structure of highly porous core–shell drug nanocarriers using solid-state NMR spectroscopy

Marianna Porcino (1, 2) , Ioanna Christodoulou (3) , Mai Dang Le Vuong (3, 4) , Ruxandra Gref (3) , Charlotte Martineau-Corcos (4, 1)

1 CEMHTI - Conditions Extrêmes et Matériaux : Haute Température et Irradiation
2 UO - Université d'Orléans
3 ISMO - Institut des Sciences Moléculaires d'Orsay
4 ILV - Institut Lavoisier de Versailles

Nano-sized metal-organic frameworks (nanoMOFs), with engineered surfaces to enhance the targeting of the drug delivery, have proven efficient as drug nanocarriers. To improve their performances a step further, it is essential to understand at the molecular level the interactions between the nanoMOF interfaces and both the surface covering groups and the drug loaded inside the micropores. Here we show how solidstate NMR spectroscopy allows us to address these issues in an aluminum-based nanoMOF coated and loaded with phosphorus-containing species.

Domaines: Matériaux

Marianna Porcino, Ioanna Christodoulou, Mai Dang Le Vuong, Ruxandra Gref, Charlotte Martineau-Corcos. New insights on the supramolecular structure of highly porous core–shell drug nanocarriers using solid-state NMR spectroscopy. RSC Advances, 2019, 9 (56), pp.32472-32475. ⟨10.1039/c9ra07383c⟩. ⟨hal-02391459⟩