Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients

Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients.

Anne-Pauline Bellanger (1, 2) , Ana Berceanu (3) , Emeline Scherer (1, 2) , Yohan Desbrosses (3) , Etienne Daguindau (3) , Steffi Rocchi (1, 2) , Laurence Millon (1, 2)

1 LCE - Laboratoire Chrono-environnement (UMR 6249)
2 Service de parasitologie et mycologie [CHRU de Besançon]
3 Service d'hématologie

We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.

Mots clés: Aspergillus fumigatus; CT; fungi; galactomannan antigen; graft-versus-host disease; hematopoietic stem-cell transplantation; immunocompromised patients; invasive fungal disease; isavuconazole; mucormycosis; qPCR; quantitative PCR; France; treatment failure; Rhizomucor; acute myeloid leukemia; antimicrobial resistance; aspergillosis; computed tomography; death; fungal co-infection

Domaines: Cancer; Hématologie; Maladies infectieuses; Mycologie

Anne-Pauline Bellanger, Ana Berceanu, Emeline Scherer, Yohan Desbrosses, Etienne Daguindau, et al.. Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients. Emerging Infectious Diseases, 2019, 25 (9), pp.1778-1779. ⟨10.3201/eid2509.190598⟩. ⟨hal-02274550⟩