What antibiotics for what pathogens? The sensitivity spectrum of isolated strains in an intensive care unit

Dana Carmen Zaha (1) , Simona Bungau (1) , Selim Aleya (2) , Delia Mirela Tit (1) , Cosmin Mihai Vesa (1) , Amorin Remus Popa (1) , Carmen Pantis (1) , Octavian Adrian Maghiar (1) , Ovidiu Gabriel Bratu (3) , Cristian Furau (4) , Radu Dumitru Moleriu (5) , Izabella Petre (6) , Lotfi Aleya (2)

1 University of Oradea
2 LCE - Laboratoire Chrono-environnement (UMR 6249)
3 UMPCD - University of Medicine and Pharmacy “Carol Davila” Bucharest
4 Life Sciences Department, Western University “Vasile Goldis” of Arad, Arad, Romania
5 Department of Mathematics, Faculty of Mathematics and Computer Science, West University of Timisoara, Romania
6 Department XII of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania

Antibiotic sensitivity spectrum of isolated strains differs according to hospital departments, the hospitals themselves, and countries. Discrepancies also exist in terms of antibiotic use and dosage. The aim of the present study is to compare the antibacterial agents, the types of infections, the number and type of pathogens, and the sensitivity to antibiotics used in the Intensive Care Unit (ICU) of the Emergency Clinical County Hospital of Oradea, Romania. Over a one-year period, data were gathered from the pharmacy computer system and medical records of inpatients. WHO Anatomical Therapeutic Chemical (ATC)/defined daily doses (DDD) methodology was used to assess drug administration data, and antibiotic use was expressed as DDD/1000 PD (patient days). The antibiotic susceptibility of isolated strains was expressed through the cumulative antibiogram. The overall consumption of antimicrobial agents was 1247.47 DDD/1000 PD. The most common drugs used were cephalosporins andfluoroquinolones (52.97% of the total). Ceftriaxone was the most commonly used, followed by levofloxacin.

Mots clés: Antibiotic; Defined daily dose

Domaines: Sciences de l'environnement

Dana Carmen Zaha, Simona Bungau, Selim Aleya, Delia Mirela Tit, Cosmin Mihai Vesa, et al.. What antibiotics for what pathogens? The sensitivity spectrum of isolated strains in an intensive care unit. Science of the Total Environment, 2019, 687, pp.118-127. ⟨10.1016/j.scitotenv.2019.06.076⟩. ⟨hal-02161167⟩