%0 Journal Article
%T Use of quantitative susceptibility mapping (QSM) in progressive multifocal leukoencephalopathy
%+ Neuroradiologie [Hôpital Gui de Chauliac]
%+ Institut des Neurosciences de Montpellier (INM)
%+ Laboratoire Charles Coulomb (L2C)
%+ CHU Montpellier
%+ Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
%+ Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI)
%+ Université de Montpellier (UM)
%A Carra-Dallière, C.
%A Menjot de Champfleur, Nicolas
%A Deverdun, Jeremy
%A Ayrignac, Xavier
%A Nerrant, E.
%A Makinson, Alain
%A Casanova, Marie-Laure
%A Labauge, Pierre
%< avec comité de lecture
%@ 0195-6108
%J American Journal of Neuroradiology
%I American Society of Neuroradiology
%V 43
%N 1
%P 6 - 10
%8 2016-02
%D 2016
%R 10.1016/j.neurad.2015.08.001
%M 26475668
%K HIV infection
%K Magnetic resonance imaging
%K Multiple sclerosis
%K Progressive multifocal leukoencephalopathy
%Z Life Sciences [q-bio]/Bioengineering/Imaging
%Z Life Sciences [q-bio]/Bioengineering/Nuclear medicine
%Z Life Sciences [q-bio]/Human health and pathology
%Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Journal articles
%X BACKGROUND:Progressive multifocal leukoencephalopathy (PML) is an opportunistic demyelinating encephalopathy related to JC virus. Its characteristics on conventional brain MRI are well known and are important for the diagnosis.OBJECTIVE:To analyze SWI hypointensities recently described in U-fibers and cortex adjacent to the white matter lesions of PML.METHODS:Prospective study including four patients with an history of definite diagnosis of PML. Clinical data were collected retrospectively. Brain MRI exams were done on a 3T magnet, including FLAIR, T2 GRE sequences and SWI.RESULTS:Four males were included (mean age: 47 years, mean PML duration: 24.2 months). Immunosuppression was related to AIDS (n=2), natalizumab for multiple sclerosis (n=1), B-cell lymphoma treated by chemotherapeutic agents and rituximab (n=1). All patients had SWI hypointensities in cortex and/or U-fibers adjacent to the white matter lesions. QSM always suggested a paramagnetic effect.CONCLUSION:SWI and T2 GRE hypointensities in cortex and U-fibers adjacent to the white matter lesions seem highly prevalent in PML, irrespective of the delay between PML onset and the MRI. QSM data suggest a paramagnetic effect.
%G English
%L hal-01887136
%U https://hal.umontpellier.fr/hal-01887136
%~ AFRIQ
%~ CNRS
%~ INM
%~ L2C
%~ MIPS
%~ BS
%~ UNIV-MONTPELLIER
%~ UM-2015-2021