%0 Journal Article
%T Lesions in deep gray nuclei after severe traumatic brain injury predict neurologic outcome
%+ CHU Pitié-Salpêtrière [AP-HP]
%+ Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM)
%+ Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
%+ Laboratoire Charles Coulomb (L2C)
%+ Department of Civil Engineering [Hamirpur]
%+ Service de Radiologie [CHU Rouen]
%+ Services de neuroradiologie [Lille]
%+ Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant)
%+ Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy]
%+ Service de neurologie [Bordeaux]
%+ Neuroprotection du Cerveau en Développement / Promoting Research Oriented Towards Early Cns Therapies (PROTECT)
%+ Johns Hopkins University School of Medicine [Baltimore]
%A Clarençon, Frédéric
%A Bardinet, Éric
%A Martinerie, Jacques
%A Pelbarg, Vincent
%A Menjot de Champfleur, Nicolas
%A Gupta, Rajiv
%A Tollard, Eléonore
%A Soto-Ares, Gustavo
%A Ibarrola, Danielle
%A Schmitt, Emmanuelle
%A Tourdias, Thomas
%A Degos, Vincent
%A Yelnik, Jérome
%A Dormont, Didier
%A Puybasset, Louis
%A Galanaud, Damien
%< avec comité de lecture
%@ 1932-6203
%J PLoS ONE
%I Public Library of Science
%V 12
%N 11
%P e0186641
%8 2017
%D 2017
%R 10.1371/journal.pone.0186641
%M 29095850
%K Humans
%K Outcome Assessment (Health Care)
%K Female
%K Male
%K Adult
%K Brain Injuries
%K Traumatic
%K Gray Matter
%Z Life Sciences [q-bio]Journal articles
%X PURPOSE: This study evaluates the correlation between injuries to deep gray matter nuclei, as quantitated by lesions in these nuclei on MR T2 Fast Spin Echo (T2 FSE) images, with 6-month neurological outcome after severe traumatic brain injury (TBI). MATERIALS AND METHODS: Ninety-five patients (80 males, mean age = 36.7y) with severe TBI were prospectively enrolled. All patients underwent a MR scan within the 45 days after the trauma that included a T2 FSE acquisition. A 3D deformable atlas of the deep gray matter was registered to this sequence; deep gray matter lesions (DGML) were evaluated using a semi-quantitative classification scheme. The 6-month outcome was dichotomized into unfavorable (death, vegetative or minimally conscious state) or favorable (minimal or no neurologic deficit) outcome. RESULTS: Sixty-six percent of the patients (63/95) had both satisfactory registration of the 3D atlas on T2 FSE and available clinical follow-up. Patients without DGML had an 89% chance (P = 0.0016) of favorable outcome while those with bilateral DGML had an 80% risk of unfavorable outcome (P = 0.00008). Multivariate analysis based on DGML accurately classified patients with unfavorable neurological outcome in 90.5% of the cases. CONCLUSION: Lesions in deep gray matter nuclei may predict long-term outcome after severe TBI with high sensitivity and specificity.
%G English
%2 https://hal.science/hal-01743095/document
%2 https://hal.science/hal-01743095/file/Lesions%20in%20deep%20gray%20nuclei%20after%20severe%20traumatic%20brain%20injury%20predict%20neurologic%20outcome.pdf
%L hal-01743095
%U https://hal.science/hal-01743095
%~ UNIV-PARIS7
%~ UPMC
%~ HCL
%~ UGA
%~ CNRS
%~ UNIV-LYON1
%~ CNS
%~ APHP
%~ L2C
%~ ICM
%~ COMUE-NORMANDIE
%~ USPC
%~ UPMC_POLE_4
%~ MIPS
%~ UNIV-MONTPELLIER
%~ UNIROUEN
%~ SORBONNE-UNIVERSITE
%~ SU-INF-2018
%~ SU-MEDECINE
%~ SU-MED
%~ UDL
%~ UNIV-LYON
%~ UNIV-PARIS
%~ TEST-HALCNRS
%~ UGA-COMUE
%~ SU-TI
%~ ALLIANCE-SU
%~ UM-2015-2021