%0 Journal Article
%T Is impaired cerebral vasoreactivity an early marker of cognitive decline in multiple sclerosis patients?
%+ Département de neurologie [Montpellier]
%+ Laboratoire Charles Coulomb (L2C)
%+ Département de Neuroradiologie[Montpellier]
%+ Institut d’Imagerie Fonctionnelle Humaine [CHU Montpellier] (I2FH)
%+ Institut de Génomique Fonctionnelle (IGF)
%+ Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
%+ Service de Neurochirurgie [CHRU Montpellier]
%+ Institut des Neurosciences de Montpellier (INM)
%+ Centre Hospitalier Universitaire [CHU Grenoble] (CHUGA)
%+ Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)
%A Metzger, Aude
%A Le Bars, Emmanuelle
%A Deverdun, Jeremy
%A Molino, François
%A Maréchal, Bénédicte
%A Picot, Marie-Christine
%A Ayrignac, Xavier
%A Carra, Clarisse
%A Bauchet, Luc
%A Krainik, Alexandre
%A Labauge, Pierre
%A Menjot de Champfleur, Nicolas
%< avec comité de lecture
%Z L2C:18-025
%@ 0720-048X
%J European Journal of Radiology
%I Elsevier
%V 28
%N 3
%P 1204-1214
%8 2018-03
%D 2018
%R 10.1007/s00330-017-5068-5
%M 29026971
%Z Computer Science [cs]/Bioinformatics [q-bio.QM]
%Z Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]Journal articles
%X The link between cerebral vasoreactivity and cognitive status in multiple sclerosis remains unclear. The aim of the present study was to investigate a potential decrease of cerebral vasoreactivity in multiple sclerosis patients and correlate it with cognitive status.;Thirty-three patients with multiple sclerosis (nine progressive and 24 remitting forms, median age: 39 years, 12 males) and 22 controls underwent MRI with a hypercapnic challenge to assess cerebral vasoreactivity and a neuropsychological assessment. Cerebral vasoreactivity, measured as the cerebral blood flow percent increase normalised by end-tidal carbon dioxide variation, was assessed globally and by regions of interest using the blood oxygen level-dependent technique. Non-parametric statistics tests were used to assess differences between groups, and associations were estimated using linear models.;;Cognitive impairment in multiple sclerosis may be mediated through decreased cerebral vasoreactivity. Cerebral vasoreactivity could therefore be considered as a marker of cognitive decline in multiple sclerosis.;• Cerebral vasoreactivity does not differ between multiple sclerosis patients and controls. • Cerebral vasoreactivity measure is linked to cognitive impairment in multiple sclerosis. • Cerebral vasoreactivity is linked to level of education in multiple sclerosis.
%G English
%L hal-01727597
%U https://hal.science/hal-01727597
%~ CNRS
%~ UNIV-MONTP1
%~ INM
%~ IGF
%~ L2C
%~ MIPS
%~ BS
%~ UNIV-MONTPELLIER
%~ UM-2015-2021