Tumor shape pulmonary mucormycosis associated with sinonasal aspergillosis in a diabetic patient

Sophie Point (1) , Frédéric Gabriel (2) , Hugues Begueret (3) , Jacques Jougon (1) , Fanny Lanternier (4) , Frederic Grenouillet (5) , Manal Abdel Fattah (6) , Emilie Catherinot (7) , Chantal Raherison (8, 9) , Elodie Blanchard (10, 8)

1 Hôpital Haut-Lévêque [CHU Bordeaux]
2 Hôpital Pellegrin, CHU de Bordeaux
3 Service d’Anatomo-Pathologie [CHU Pessac]
4 Centre d'infectiologie Necker-Pasteur [CHU Necker]
5 LCE - Laboratoire Chrono-environnement (UMR 6249)
6 Service des Maladies Infectieuses et Tropicales [CHRU Nancy]
7 Hôpital Foch [Suresnes]
8 CHU Bordeaux
9 BPH - Bordeaux population health
10 IAC - Institut Agronomique Néo-Calédonien

Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. While receiving liposomal amphotericin B, a sinusal aspergillosis due to Aspergillus fumigatus occurred. Evolution was slowly favorable under antifungal tritherapy by liposomal amphotericin B, posaconazole and caspofungin.

Mots clés: BAL; Bronchoalveolar Lavage; Bronchial obstruction; Diabetic ketoacidosis; Fungal infection; GVH; raft Versus Host disease; PCR; Polymerase Chain Reaction; Pulmonary mucormycosis; Sinusal aspergillosis

Domaines: Santé

Sophie Point, Frédéric Gabriel, Hugues Begueret, Jacques Jougon, Fanny Lanternier, et al.. Tumor shape pulmonary mucormycosis associated with sinonasal aspergillosis in a diabetic patient. Medical Mycology Case Reports, 2018, 19, pp.13 - 17. ⟨10.1016/j.mmcr.2017.08.001⟩. ⟨hal-01667759⟩