Photomodulation of DNA-Templated Supramolecular Assemblies

Jenifer Rubio-Magnieto (1) , Tuan-Anh Phan (2, 3) , Mathieu Fossépré (1) , Valérie Matot (1) , Jeremie Knoops (1) , Thibaut Jarrosson (2) , Pascal Dumy (3) , Françoise Serein-Spirau (2) , Claude Niebel (2) , Sébastien Ulrich (3) , Mathieu Surin (1)

1 Laboratory for Chemistry of Novel Materials
2 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
3 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

Anew type of DNA ligand that contains a phosphate-binding group and a photoresponsive azobenzene moiety is reported. When the azobenzene is in trans configuration, the ligand binds to the minor groove of a double-stranded DNA, whereas it partially desorbs upon trans –cis isomerisation with light.The ability to photoswitch the ligand upon interaction with DNA is evidenced by (chir)optical signatures, and deciphered by the differences of binding geometry, stability, and dynamics of the DNA/ligand complexes for the two isomers. We exploit these properties to photomodulate DNA-templated self-assembly, through the incorporation of another pi-stacking DNA ligand, which together with the photoresponsive ligand form mixed supramolecular complexes along DNA. Our study demonstrates that well-designed photoresponsive DNA binders can be used to modulate multicomponent supramolecular DNA assemblies.

Mots clés: DNA structures; isomerization; photochemistry; self-assembly; supramolecular chemistry

Domaines: Chimie organique

Jenifer Rubio-Magnieto, Tuan-Anh Phan, Mathieu Fossépré, Valérie Matot, Jeremie Knoops, et al.. Photomodulation of DNA-Templated Supramolecular Assemblies. Chemistry - A European Journal, 2018, 24, pp.706-714. ⟨10.1002/chem.201704538⟩. ⟨hal-01666843⟩