%0 Conference Proceedings
%T An intravascular coronary plaque elasticity reconstruction method using limited depth penetration ultrasound signals
%+ Dynamiques Cellulaire, Tissulaire & Microscopie fonctionnelle (TIMC-IMAG-DyCTiM)
%+ Laboratoire de Mécanique et Génie Civil (LMGC)
%+ Biomécanique des Interactions et de l'Organisation des Tissus et des Cellules (BIOTIC)
%+ Hospices Civils de Lyon (HCL)
%+ Université Claude Bernard Lyon 1 (UCBL)
%+ Institut National de la Santé et de la Recherche Médicale (INSERM)
%+ University of Rochester [USA]
%+ National Institutes of Health [Bethesda, MD, USA] (NIH)
%+ Centre Hospitalier de l'Université de Montréal (CHUM)
%+ Polytech Annecy-Chambéry (EPU [Ecole Polytechnique Universitaire de l'Université de Savoie])
%A Tacheau, Antoine
%A Lefloch, Simon
%A Finet, Gérard
%A Doyley, Marvin, M
%A Pettigrew, Roderic, I
%A Cloutier, Guy
%A Ohayon, Jacques
%< avec comité de lecture
%B 40ème congrès de la Société de Biomécanique
%C Paris, France
%3 Actes du 40ème congrès de la Société de Biomécanique
%V 18
%P 2066 - 2067
%8 2015-10-28
%D 2015
%R 10.1080/10255842.2015.1069604
%K inverse problem
%K linear elasticity
%K modulography
%K vulnerable plaques
%K coronary disease
%Z Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]Conference papers
%X Vulnerable atherosclerotic plaque (VP) rupture is the leading cause of acute coronary syndrome, myocardial infarction andstroke in the Western world (Go et al. 2013). Although past studies have identified fibrous cap thickness (Capthick) as theprimary predictor of coronary plaque rupture (Virmani et al. 2006), biomechanical studies have recognized peak cap stress(PCS) as an additional key predictor of plaque disruption (Ohayon et al. 2008). Quantification of PCS amplitude requiresnot only an accurate description of plaque morphology but also a precise knowledge of the mechanical properties of plaquecomponents. An early and accurate determination of these properties remains an essential step to implement preventivetherapeutic strategies.A previous approach (named iMOD for imaging modulography) has been conducted by our group to reconstructthe Young’s modulus map (i.e. modulogram) from intravascular ultrasound (IVUS) strain-elastogram (Le Floc’h et al. 2009). However,one major limitation of such a method is the need to accurately estimate the strain field in the entire lesion, which may beoften difficult when using HD-IVUS techniques with limited depth penetration signals (Kobayashi et al. 2014). Therefore, an extendediMOD approach (E-iMOD), based on the continuum mechanics theory prescribing the strain field in the limited atheroscleroticendoluminal region, was designed and successfully applied to coronary lesions of patients imaged in vivo with IVUS.
%G English
%2 https://hal.science/hal-01576862/document
%2 https://hal.science/hal-01576862/file/Conf_LeFloch_al_Intravascular_coronary_plaque_2015.pdf
%L hal-01576862
%U https://hal.science/hal-01576862
%~ INSERM
%~ UNIV-SAVOIE
%~ HCL
%~ UGA
%~ IMAG
%~ CNRS
%~ UNIV-GRENOBLE1
%~ UNIV-LYON1
%~ INPG
%~ LMGC
%~ TIMC-IMAG
%~ TIMC-IMAG-DYCTIM
%~ MIPS
%~ UNIV-MONTPELLIER
%~ UDL
%~ UNIV-LYON
%~ USMB-COMUE
%~ UM-2015-2021