%0 Journal Article
%T Simple and Specific Grafting of Antibacterial Peptides on Silicone Catheters
%+ Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM)
%+ Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM)
%+ Hydrosciences Montpellier (HSM)
%+ Laboratoire de Réactivité de Surface (LRS)
%A Pinese, Coline
%A Jebors, Said
%A Echalier, Cécile
%A Licznar-Fajardo, Patricia
%A Garric, Xavier
%A Humblot, Vincent
%A Calers, Christophe
%A Martinez, Jean
%A Mehdi, Ahmad
%A Subra, Gilles
%< avec comité de lecture
%@ 2192-2640
%J Advanced Healthcare Materials
%I Wiley
%V 5
%N 23
%P 3067 - 3073
%8 2016-12
%D 2016
%R 10.1002/adhm.201600757
%K antibacterial silicone
%K hybrid materials
%K silylated peptides
%K surface modification
%Z Chemical SciencesJournal articles
%X To fight against nosocomial infection initiated by colonization of medical devices, a strategy enabling the direct and fast functionalization of silicone surfaces is proposed. This strategy proceeds in a site-specific way using original hybrid silylated antibacterial peptides. This safe and up-scalable method guarantees a covalent and robust immobilization with the correct orientation of the bioactive moiety. Importantly it also avoids multi-step chemical modifications of the surface or multi-layer polymer coatings. As proof of concept, antibacterial silicone catheter has been prepared whose immediate and long term efficiency is superior by comparison to similar silver-embedded materials.
%G English
%L hal-01547344
%U https://hal.sorbonne-universite.fr/hal-01547344
%~ INSU
%~ UPMC
%~ CNRS
%~ ENSC-MONTPELLIER
%~ ICG
%~ IBMM
%~ HSM
%~ LRS
%~ INC-CNRS
%~ UPMC_POLE_2
%~ CHIMIE
%~ UNIV-MONTPELLIER
%~ SORBONNE-UNIVERSITE
%~ SU-SCIENCES
%~ ALLIANCE-SU
%~ UM-2015-2021
%~ TEST2-HALCNRS
%~ CHIMIE-SU