Serial use of pentamidine and miltefosine for treating Leishmania infantum-HIV coinfection.

Jean-François Faucher (1) , David Morquin (2) , Jacques Reynes (3) , Catherine Chirouze (4, 5, 6) , Bruno Hoen (7) , Vincent Le Moing (8)

1 UPJV - Université de Picardie Jules Verne
2 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
3 Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France
4 LCE - Laboratoire Chrono-environnement (UMR 6249)
5 Service des maladies infectieuses et tropicales
6 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
7 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
8 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes

Liposomal amphotericin B (LAmb) may fail to heal Leishmania infantum visceral leishmaniasis (VL) in the immunodeficient host. There are currently no guidelines on how to treat such patients and efficacy of miltefosine monotherapy seems limited in this indication. We present 2 cases of patients with VL and AIDS for which LAmb had to be interrupted (one because of toxicity, one because of treatment failure) and who were treated effectively with pentamidine followed by miltefosine.

Mots clés: Aids; Liposomal amphotericin B; Miltefosine; Pentamidine; Visceral leishmaniasis

Domaines: Médecine humaine et pathologie

Jean-François Faucher, David Morquin, Jacques Reynes, Catherine Chirouze, Bruno Hoen, et al.. Serial use of pentamidine and miltefosine for treating Leishmania infantum-HIV coinfection.. Parasitology International, 2016, 65 (5), pp.444-6. ⟨10.1016/j.parint.2016.06.009⟩. ⟨hal-01509592⟩