%0 Journal Article
%T Monitoring Biopolymer Degradation by Taylor Dispersion Analysis
%+ Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM)
%+ Laboratoire Charles Coulomb (L2C)
%A Chamieh, Joseph
%A Biron, Jean Philippe
%A Cipelletti, Luca
%A Cottet, Herve
%< avec comité de lecture
%Z L2C:15-305
%@ 1525-7797
%J Biomacromolecules
%I American Chemical Society
%V 16
%N 12
%P 3945-3951
%8 2015-12-03
%D 2015
%R 10.1021/acs.biomac.5b01260
%Z Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft]Journal articles
%X This work aims at demonstrating the interest ofmodern Taylor dispersion analysis (TDA), performed in narrow internal diameter capillary, for monitoring biopolymer degradations. Hydrolytic and enzymatic degradations ofdendrigraft poly-L-lysine taken as model compounds havebeen performed and monitored by TDA at differentdegradation times. Different approaches for the dataprocessing of the taylorgrams are compared, including simpleintegration of the taylorgram, curve fitting with a finite numberof Gaussian peaks, cumulant-like method and ConstrainedRegularized Linear Inversion approach. Valuable informationon the kinetics of the enzymatic/hydrolytic degradation reactions and on the degradation process can be obtained by TDA.
%G English
%L hal-01407655
%U https://hal.science/hal-01407655
%~ CNRS
%~ ENSC-MONTPELLIER
%~ IBMM
%~ L2C
%~ INC-CNRS
%~ MIPS
%~ CHIMIE
%~ UNIV-MONTPELLIER
%~ UM-2015-2021
%~ TEST2-HALCNRS