%0 Journal Article
%T Mechanochemical Preparation of 3,5-Disubstituted Hydantoins from Dipeptides and Unsymmetrical Ureas of Amino Acid Derivatives
%+ Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM)
%+ Rudjer Boskovic Institute [Zagreb]
%+ Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM)
%A Konnert, Laure
%A Gonnet, Lori
%A Halasz, Ivan
%A Suppo, Jean-Simon
%A Marcia de Figueiredo, Renata
%A Campagne, Jean-Marc
%A Lamaty, Frederic
%A Martinez, Jean
%A Colacino, Evelina
%< avec comité de lecture
%@ 0022-3263
%J Journal of Organic Chemistry
%I American Chemical Society
%V 81
%N 20
%P 9802-9809
%8 2016
%D 2016
%R 10.1021/acs.joc.6b01832
%K Hydantoin
%K ball-mill
%K amino acid
%K CDI
%K carbonyl diimidazole
%K Dipeptide
%K Mechanochemistry
%K Mechanosynthesis
%Z Chemical Sciences/Organic chemistryJournal articles
%X 5-Substituted-3-(alkoxycarbonyl)alkyl-hydantoin derivatives were prepared by mechanochemistry from amino esters or dipeptides, via a 1,1′-carbonyldiimidazole-mediated one-pot/two-step cyclization reaction involving amino acid unsymmetrical urea A and carboxy-imidazolyl-dipeptide ester B intermediates. Comparative experiments in solution were also performed. The successful preparation of an antibacterial agent precursor was also investigated.
%G English
%2 https://hal.science/hal-01396871/document
%2 https://hal.science/hal-01396871/file/Hal-111-2016.pdf
%L hal-01396871
%U https://hal.science/hal-01396871
%~ CNRS
%~ ENSC-MONTPELLIER
%~ ICG
%~ IBMM
%~ INC-CNRS
%~ CHIMIE
%~ UNIV-MONTPELLIER
%~ UM-2015-2021
%~ TEST2-HALCNRS