%0 Journal Article
%T Redox Reducible and Hydrolytically Degradable PEG–PLA Elastomers as Biomaterial for Temporary Drug-Eluting Medical Devices
%+ Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM)
%A Rupnik, Simona
%A Buwalda, Sytze
%A Dejean, Stéphane
%A Bethry, Audrey
%A Garric, Xavier
%A Coudane, Jean
%A Nottelet, Benjamin
%< avec comité de lecture
%@ 1616-5187
%J Macromolecular Bioscience
%I Wiley-VCH Verlag
%8 2016-12-13
%D 2016
%R 10.1002/mabi.201600132
%M 27377673
%K Degradation
%K Drug release
%K Elastomers
%K Medical device
%K Polyesters
%K Redox
%Z Chemical Sciences/Material chemistryJournal articles
%X With the aim to develop biomaterials for temporary medical devices, a series of novel reducible and/or degradable elastomers has been prepared from PLA-b-PEG-b-PLA copolymers photo-crosslinked with diallyl sulfide or pentaerythritol tetrakis(3-mercaptopropionate). Thermal and mechanical properties, including elastic limit and Young modulus, are assessed. Degradation is then evaluated under standard hydrolytic conditions. Reducibility of a selected elastomer is then illustrated using 2-mercaptoethanol or glutathione as reducing agents. The redox-sensitivity of the selected elastomer and the possibility to modulate the degradability are shown. Considering drug-eluting elastomeric devices applications, anti-inflammatory drug ibuprofen loading is illustrated with the two simplest elastomer formulations. A rapid or slow linear release is observed as a function of the low or high molecular weight of the triblock pre-polymers. Finally, the cytocompatibility of the degradable elastomers is assessed with regard to their potential to favor or inhibit L929 murine fibroblasts proliferation as a function of the hydrophilicity/hydrophobicity of the triblock copolymers.
%G English
%2 https://hal.science/hal-01369303/document
%2 https://hal.science/hal-01369303/file/S.%20Rupnik%20Article%20final%20Hal%20version.pdf
%L hal-01369303
%U https://hal.science/hal-01369303
%~ CNRS
%~ ENSC-MONTPELLIER
%~ IBMM
%~ OPENAIRE
%~ INC-CNRS
%~ CHIMIE
%~ UNIV-MONTPELLIER
%~ UM-2015-2021
%~ TEST2-HALCNRS