%0 Journal Article
%T Foci of cyclin A2 interact with actin and RhoA in mitosis
%+ Laboratoire Charles Coulomb (L2C)
%A Loukil, Abdelhalim
%A Izard, Fanny
%A Georgieva, Mariya
%A Mashayekhan, Shaereh
%A Blanchard, Jean-Marie
%A Parmeggiani, Andrea
%A Peter, Marion
%< avec comité de lecture
%Z L2C:16-101
%@ 2045-2322
%J Scientific Reports
%I Nature Publishing Group
%V 6
%P 27215
%8 2016-06-09
%D 2016
%R 10.1038/srep27215
%Z Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]
%Z Nonlinear Sciences [physics]/Cellular Automata and Lattice Gases [nlin.CG]
%Z Nonlinear Sciences [physics]/Adaptation and Self-Organizing Systems [nlin.AO]
%Z Life Sciences [q-bio]/Cancer
%Z Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
%Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN]
%Z Physics [physics]/Physics [physics]/Physics and Society [physics.soc-ph]Journal articles
%X Cyclin A2 is a key player in the regulation of the cell cycle. Its degradation in mid-mitosis depends primarily on the ubiquitin-proteasome system (UPS), while autophagy also contributes. However, a fraction of cyclin A2 persists beyond metaphase. In this work, we focus on cyclin A2-rich foci detected in mitosis by high resolution imaging and analyse their movements. We demonstrate that cyclin A2 interacts with actin and RhoA during mitosis, and that cyclin A2 depletion induces a dramatic decrease in active RhoA in mitosis. Our data suggest cyclin A2 participation in RhoA activation in late mitosis.
%G English
%2 https://hal.science/hal-01345990/document
%2 https://hal.science/hal-01345990/file/srep27215.pdf
%L hal-01345990
%U https://hal.science/hal-01345990
%~ CNRS
%~ L2C
%~ TDS-MACS
%~ MIPS
%~ UNIV-MONTPELLIER
%~ UM-2015-2021
%~ FRM