%0 Conference Paper
%F Oral 
%T Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis
%+ Institut de Mathématiques de Marseille (I2M)
%+ Hôpital de la Timone [CHU - APHM] (TIMONE)
%+ Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2)
%A Barlukova, Ayuna
%A Honoré, Stéphane
%A Hubert, Florence
%F Invité
%< avec comité de lecture
%3 ITM Web of Conferences
%B Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology
%C Paris, France
%I EDP Sciences
%V 5
%N 00011
%P 4 pages
%8 2015-03-16
%D 2015
%R 10.1051/itmconf/20150500011
%K microtubule
%K cytosqueleton
%K cell division
%K cell migration
%K cancer process
%K anti-cancer treatment
%K GTP-tubulin hydrolysis
%Z Mathematics [math]/Analysis of PDEs [math.AP]
%Z Life Sciences [q-bio]/CancerConference papers
%X Microtubules, components of the cytosqueleton, play an important role in cell division, cell migration and thus in the cancer proccess through dynamic instability. Therefore they are an important target for anti-cancer treatment. Proper modelling of dynamic instability is a crucial tool to understand the mechanism of action of microtubule targeting agents. In this paper, we propose a new concept for GTP-tubulin hydrolysis which allow the model to accurately reproduce microtubule dynamics observed in vitro or in cells. This approach will be more appropriate to take study the effects of drugs.
%G English
%L hal-01322761
%U https://hal.science/hal-01322761
%~ CNRS
%~ UNIV-AMU
%~ EC-MARSEILLE
%~ I2M
%~ I2M-2014-
%~ TDS-MACS