%0 Journal Article
%T Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses
%+ Spanish National Cancer Research Center (CNIO)
%+ Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM)
%+ Universitat de València (UV)
%+ Institut de Mathématiques de Marseille (I2M)
%A Ibáñez, Kristina
%A Boullosa, César
%A Tabarés-Seisdedos, Rafael
%A Baudot, Anaïs
%A Valencia, Alfonso
%< avec comité de lecture
%@ 1553-7390
%J PLoS Genetics
%I Public Library of Science
%V 10
%N 2
%P e1004173
%8 2014
%D 2014
%R 10.1371/journal.pgen.1004173
%K Central nervous system
%K Gene expression
%K Parkinson disease
%K Alzheimer's disease
%K Meta-analysis
%K Colorectal cancer
%K Schizophrenia
%K Malaria
%Z Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
%Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
%Z Life Sciences [q-bio]/Santé publique et épidémiologie
%Z Life Sciences [q-bio]/Cancer
%Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Journal articles
%X There is epidemiological evidence that patients with certain Central Nervous System (CNS) disorders have a lower than expected probability of developing some types of Cancer. We tested here the hypothesis that this inverse comorbidity is driven by molecular processes common to CNS disorders and Cancers, and that are deregulated in opposite directions. We conducted transcriptomic meta-analyses of three CNS disorders (Alzheimer's disease, Parkinson's disease and Schizophrenia) and three Cancer types (Lung, Prostate, Colorectal) previously described with inverse comorbidities. A significant overlap was observed between the genes upregulated in CNS disorders and downregulated in Cancers, as well as between the genes downregulated in CNS disorders and upregulated in Cancers. We also observed expression deregulations in opposite directions at the level of pathways. Our analysis points to specific genes and pathways, the upregulation of which could increase the incidence of CNS disorders and simultaneously lower the risk of developing Cancer, while the downregulation of another set of genes and pathways could contribute to a decrease in the incidence of CNS disorders while increasing the Cancer risk. These results reinforce the previously proposed involvement of the PIN1 gene, Wnt and P53 pathways, and reveal potential new candidates, in particular related with protein degradation processes.
%G English
%2 https://hal.science/hal-01266780/document
%2 https://hal.science/hal-01266780/file/journal.pgen.1004173.PDF
%L hal-01266780
%U https://hal.science/hal-01266780
%~ CNRS
%~ UNIV-AMU
%~ EC-MARSEILLE
%~ SANTE_PUB_INSERM
%~ I2M
%~ I2M-2014-