%0 Journal Article
%T Drug-Polymer Electrostatic Complexes as New Structuring Agents for the Formation of Drug-Loaded Ordered Mesoporous Silica
%+ Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM)
%+ Laboratoire Charles Coulomb (L2C)
%+ Matière Molle
%+ CERM
%A Molina, Emilie
%A Warnant, Jerome
%A Mathonnat, Melody
%A Bathfield, Mael
%A In, Martin
%A Laurencin, Danielle
%A Jérôme, Christine
%A Lacroix-Desmazes, Patrick
%A Marcotte, Nathalie
%A Gerardin, Corine
%< avec comité de lecture
%Z L2C:15-241
%@ 0743-7463
%J Langmuir
%I American Chemical Society
%V 31
%N 47
%P 12839-12844
%8 2015-12-01
%D 2015
%R 10.1021/acs.langmuir.5b03221
%Z Chemical Sciences/Polymers
%Z Chemical Sciences/Material chemistry
%Z Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci]Journal articles
%X Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases. This phase behavior was evidenced by using poly(acrylic acid)-block-poly(ethylene oxide) block copolymers in the presence of silica precursors, and this allowed preparing drug-loaded mesoporous silica directly from the drug-polymer complexes. The novel synthetic strategy of the hybrid materials is highly efficient, avoiding waste and multistep processes; it also ensures optimal drug loading and provides pH-dependence of the drug release from the materials.
%G English
%L hal-01257693
%U https://hal.science/hal-01257693
%~ CNRS
%~ ENSC-MONTPELLIER
%~ ICG
%~ L2C
%~ INC-CNRS
%~ MIPS
%~ CHIMIE
%~ UNIV-MONTPELLIER
%~ ANR
%~ UM-2015-2021
%~ TEST2-HALCNRS