201Tl+-labelled Prussian blue nanoparticles as contrast agents for SPECT scintigraphy.

Marine Perrier (1) , Muriel Busson (2) , Giovanni Massasso (1) , Jérome Long (1) , Vincent Boudousq (3, 2) , Jean-Pierre Pouget (3, 2) , Suzanne Peyrottes (4) , Christian Périgaud (4) , Constança Porredon-Guarch (5) , Joaquin de Lapuente , Miquel Borras , Joulia Larionova (1) , Yannick Guari (1)

1 ICGM ICMMM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 IRCM - U896 Inserm - UM1 - Institut de recherche en cancérologie de Montpellier
3 Service de Médecine Nucléaire [Nîmes]
4 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
5 UTOX-PCB - Unit of experimental Toxicology and Ecotoxicology

Prussian blue (PB) and its analogues on the nanometric scale are exciting nano-objects that combine the advantages of molecular-based materials and nanochemistry. Herein, we demonstrate that ultra-small PB nanoparticles of 2–3 nm can be easily labelled with radioactive 201Tl+ to obtain new nanoprobes as radiotracers for 201-thallium-based imaging.

Domaines: Chimie organique; Cancer

Marine Perrier, Muriel Busson, Giovanni Massasso, Jérome Long, Vincent Boudousq, et al.. 201Tl+-labelled Prussian blue nanoparticles as contrast agents for SPECT scintigraphy.. Nanoscale, 2014, 6 (22), pp.13425-13429. ⟨10.1039/c4nr03044c⟩. ⟨hal-01084124⟩