Sévérité de la dermatite atopique et taux de vitamine D : étude transversale

S. Ronceray (1) , L. Benkalfate (1) , C. Saillard (1) , K. Ezzedine (2) , H. Adamski (1) , A. Dupuy (1, 3) , C. Droitcourt (1)

1 Service de Dermatologie [Rennes] = Dermatology [Rennes]
2 Service de dermatologie Hôpital Saint-André Bordeaux
3 CIC - Centre d'Investigation Clinique [Rennes]

Background Contradictory findings have recently been published on the association between atopic dermatitis (AD) severity and vitamin D deficiency. The aim of this study was to examine the correlation between 25-hydroxyvitamin D (25(OH)D) concentration and \AD\ severity. Patients and methods A cross-sectional study was conducted from June 2011 to March 2013 in dermatology departments in adults and children with a diagnosis of AD. The severity of \AD\ was assessed using the \SCORAD\ and PO-SCORAD indexes and serum 25(OH)D concentrations were determined for all patients. Results Sixty patients were included: 30 with severe \AD\ and 30 with mild-to-moderate AD. The 25(OH)D concentration was lower in patients with severe \AD\ than in patients with mild-to-moderate \AD\ (15.9 ± 8.3 ng/mL vs. 21.5 ± 8.2 ng/mL; P = 0.01). There was a negative correlation between 25(OH)D concentration and respectively, \SCORAD\ (r = −0.47; P < 0.001) and PO-SCORAD (r = −0.4; P = 0.004) values. The correlation between 25(OH)D concentrations and \SCORAD\ values remained valid after adjustment for age, phototype and season. Conclusion This study demonstrated an association between vitamin D deficiency and \AD\ severity but showed no causal link between these variables. Confounding variables such as sun exposure and socioeconomic status were not recorded. A large-sale, comparative interventional study could confirm a real link between these two variables.

Mots clés: Atopic dermatitis; Vitamin D; Deficiency; Dermatite atopique; Vitamine D; Déficit

Domaines: Sciences du Vivant [q-bio]

S. Ronceray, L. Benkalfate, C. Saillard, K. Ezzedine, H. Adamski, et al.. Sévérité de la dermatite atopique et taux de vitamine D : étude transversale. Annales de Dermatologie et de Vénéréologie, 2014, 141 (4), pp.265 - 271. ⟨10.1016/j.annder.2014.01.013⟩. ⟨hal-01060932⟩